CCL25 靶点信息

CCL25 分子靶点信息概述

  • 分子名：CCL25, C-C motif chemokine ligand 25
  • 基因家族：Chemokine ligands
  • 别名：TECK; Ckb15
  • 曾用名：SCYA25
  • 全称：Ck beta-15; thymus expressed chemokine; TECKvar; small inducible cytokine subfamily A (Cys-Cys), member 25; chemokine (C-C motif) ligand 25

CCL25 分子靶点综述

趋化因子C-C基序配体25（CCL25），也称为胸腺表达趋化因子（TECK），是一种趋化因子,由胸腺的基质细胞和小肠的上皮细胞（特别是空肠和回肠）产生。CCL25诱导数个淋巴细胞群体归巢到小肠，包括整合素a4b7 +γ/δT细胞，整合素aEb7 + CD8 + T细胞和产生IgA的浆细胞。CCL25在结合趋化因子受体CCR9后起作用。CCL25在类风湿性关节炎中吸引CCR9 +单核细胞和巨噬细胞，在动脉粥样硬化中吸引CCR9 +巨噬细胞。另外，CCL25似乎是招募MSC并因此促进原位再生的新有希望的候选人。在癌症中，CCL25促进黑色素瘤细胞向小肠的转移，某些乳腺癌的迁移和侵袭以及间充质基质细胞对多发性骨髓瘤的吸引。

CCL25, C-C motif chemokine ligand 25 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CCL25 分子靶点信息

  • 分子名：CCL25, C-C motif chemokine ligand 25
  • 别称：
    • C-C motif chemokine 25
    • chemokine (C-C motif) ligand 25
    • chemokine TECK
    • Ck beta-15
    • Ckb15
    • MGC150327
    • SCYA25
    • small inducible cytokine subfamily A (Cys-Cys), member 25
    • small-inducible cytokine A25
    • TECK
    • TECKvar
    • thymus expressed chemokine
    • thymus-expressed chemokine
  • 基因序列：NCBI_Gene: 6370
  • 蛋白序列：UniProtKB: O15444

人 Human CCL25靶点分子功能（预测）

Enables CCR10 chemokine receptor binding activity and chemokine activity. Involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; negative regulation of leukocyte tethering or rolling; and positive regulation of cell-matrix adhesion. Predicted to be located in extracellular region. Predicted to be active in extracellular space.

小鼠 Mouse Ccl25 分子靶点信息

小鼠 Mouse Ccl25 靶点分子功能（预测）

Enables chemokine activity. Acts upstream of or within chemotaxis and leukocyte migration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in 3rd branchial pouch; central nervous system; hemolymphoid system; retina; and thymus/parathyroid primordium. Orthologous to human CCL25 (C-C motif chemokine ligand 25).

大鼠 Rat Ccl25 分子靶点信息

  • 分子名：Ccl25, C-C motif chemokine ligand 25
  • 别称：
    • C-C motif chemokine 25
    • chemokine (C-C motif) ligand 25
    • LOC360750
    • MGC125074
  • 基因序列：NCBI_Gene: 360750
  • 蛋白序列：UniProtKB: Q32PX4

大鼠 Rat Ccl25 靶点分子功能（预测）

Predicted to enable CCR10 chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and negative regulation of leukocyte tethering or rolling. Predicted to act upstream of or within chemotaxis and leukocyte migration. Predicted to be active in extracellular space. Orthologous to human CCL25 (C-C motif chemokine ligand 25).

CCL25 分子产品列表

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