CCL13 靶点信息

CCL13 分子靶点信息概述

  • 分子名：CCL13, C-C motif chemokine ligand 13
  • 基因家族：Chemokine ligands
  • 别名：MCP-4; NCC-1; SCYL1; CKb10; MGC17134
  • 曾用名：SCYA13
  • 全称：small inducible cytokine subfamily A (Cys-Cys), member 13; chemokine (C-C motif) ligand 13

CCL13 分子靶点综述

趋化因子CC配体13(CCL13)，又名单核细胞趋化蛋白4(MCP-4)，是CC趋化因子家族中的小分子细胞因子。它的基因位于人类17号染色体上由其它CC趋化因子构成的大型集群中。CCL13通过结合细胞表面G蛋白连接的趋化因子受体如CCR2、CCR3和CCR5来趋化单核细胞、嗜酸粒细胞、T淋巴细胞和嗜碱粒细胞。CCL13活性参与过敏性反应如哮喘。炎症细胞因子如IL-1和TNF-α可诱导CCL13。

CCL13, C-C motif chemokine ligand 13 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CCL13 分子靶点信息

  • 分子名：CCL13, C-C motif chemokine ligand 13
  • 别称：
    • C-C motif chemokine 13
    • chemokine (C-C motif) ligand 13
    • CK-beta-10
    • CKb10
    • MCP-4
    • MGC17134
    • monocyte chemoattractant protein 4
    • monocyte chemotactic protein 4
    • NCC-1
    • NCC1
    • new CC chemokine 1
    • SCYA13
    • SCYL1
    • small inducible cytokine subfamily A (Cys-Cys), member 13
    • small-inducible cytokine A13
  • 基因序列：NCBI_Gene: 6357
  • 蛋白序列：UniProtKB: Q99616

人 Human CCL13靶点分子功能（预测）

Enables chemokine activity. Involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; eosinophil chemotaxis; and regulation of cell shape. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in multiple sclerosis.

小鼠 Mouse Ccl11 分子靶点信息

  • 分子名：Ccl11, chemokine (C-C motif) ligand 11
  • 别称：
    • eotaxin
    • Scya11
    • small inducible cytokine A11
  • 基因序列：NCBI_Gene: 20292
  • 蛋白序列：

小鼠 Mouse Ccl11 靶点分子功能（预测）

Predicted to enable CCR3 chemokine receptor binding activity; chemokine activity; and protein dimerization activity. Involved in several processes, including modulation of age-related behavioral decline; negative regulation of neurogenesis; and positive regulation of angiogenesis. Acts upstream of or within branching involved in mammary gland duct morphogenesis and mammary duct terminal end bud growth. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in embryo; endocardial lining; liver parenchyma; liver vasculature; and yolk sac blood vessel. Human ortholog(s) of this gene implicated in asthma; human immunodeficiency virus infectious disease; hyperglycemia; and multiple sclerosis. Orthologous to several human genes including CCL11 (C-C motif chemokine ligand 11).

大鼠 Rat Ccl12 分子靶点信息

  • 分子名：Ccl12, chemokine (C-C motif) ligand 12
  • 别称：
    • LOC287562
    • MCP-5
    • monocyte chemotactic protein 5
  • 基因序列：NCBI_Gene: 287562
  • 蛋白序列：UniProtKB: D4ABS1

大鼠 Rat Ccl12 靶点分子功能（预测）

Predicted to enable CCR2 chemokine receptor binding activity and chemokine activity. Involved in negative regulation of leukocyte proliferation and positive regulation of leukocyte migration. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; aggressive periodontitis; autoimmune disease (multiple); gastrointestinal system cancer (multiple); and tuberculosis (multiple). Orthologous to several human genes including CCL8 (C-C motif chemokine ligand 8).

CCL13 分子产品列表

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