文章目录[隐藏]
CA14 分子靶点信息概述
- 分子名:CA14, carbonic anhydrase 14
- 基因家族:Carbonic anhydrases
- 全称:carbonic anhydrase XIV
CA14 分子靶点综述
碳酸酐酶是一个庞大的锌金属酶家族,催化二氧化碳可逆的水合作用。碳酸酐酶参与多种生物学过程,包括呼吸、钙化、酸碱平衡、骨吸收以及房水、脑脊液、唾液和胃酸的形成。他们具有广泛的组织分布和亚细胞定位多样性。碳酸酐酶14 (CA14)是一个多肽,由一个细胞外N-末端催化结构域、一个跨膜区和一个短的有潜在磷酸化位点的胞内C-末端片段组成。CA14在脑神经元的胞体和轴突质膜、肝脏的肝细胞质膜上表达,也在肾脏特别是近端小管顶膜上优先表达。CA14与另一个跨膜CA异构体CA12有最高的序列相似性。然而,它们有不同的组织特异性表达模式,因此可能发挥不同的生理作用。CA14和CA4可通过促进AE3介导的Cl- – HCO3-交换来调节海马神经元的胞内pH。
CA14, carbonic anhydrase 14 分子靶点种属信息
人 Human CA14 分子靶点信息
- 分子名:CA14, carbonic anhydrase 14
- 别称:
- CA-XIV
- carbonate dehydratase XIV
- carbonic anhydrase XIV
- carbonic dehydratase
- CAXiV
- 基因序列:NCBI_Gene: 23632
- 蛋白序列:UniProtKB: Q9ULX7
人 Human CA14靶点分子功能(预测)
Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be integral component of membrane. Predicted to be active in plasma membrane.
小鼠 Mouse Car14 分子靶点信息
- 分子名:Car14, carbonic anhydrase 14
- 别称:
- AW536446
- CA XIV
- expressed sequence AW536446
- 基因序列:NCBI_Gene: 23831
- 蛋白序列:
小鼠 Mouse Car14 靶点分子功能(预测)
Enables carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to act upstream of or within carbon dioxide transport and regulation of pH. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; cranium; epiblast; eye; and urinary system. Orthologous to human CA14 (carbonic anhydrase 14).
大鼠 Rat Ca14 分子靶点信息
- 分子名:Ca14, carbonic anhydrase 14
- 别称:
- Car14
- carbonic anhydrase XIV
- 基因序列:NCBI_Gene: 791259
- 蛋白序列:UniProtKB: A2IBE0
大鼠 Rat Ca14 靶点分子功能(预测)
Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human CA14 (carbonic anhydrase 14).
CA14 分子产品列表
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- EK1225
- ELISA试剂盒
Human Carbonic Anhydrase XIV/CA14 ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥1,600.00 – ¥2,650.00