CA12 靶点信息

CA12 分子靶点信息概述

  • 分子名：CA12, carbonic anhydrase 12
  • 基因家族：Carbonic anhydrases
  • 别名：HsT18816
  • 全称：carbonic anhydrase XII

CA12 分子靶点综述

碳酸酐酶是一个庞大的锌金属酶家族，催化二氧化碳可逆的水合作用。碳酸酐酶参与多种生物学过程，包括呼吸、钙化、酸碱平衡、骨吸收以及房水、脑脊液、唾液和胃酸的形成。 碳酸酐酶12 (CA12)是一个I型膜蛋白，在正常组织如肾脏、结肠和胰腺中高度表达，并在10%的肾透明细胞癌中过度表达。目前已鉴定编码CA12不同异构体的两种转录变异体。由于流汗会消耗盐分，研究者认为CA12的基因突变与常染色体隐性遗传的低钠血症有关。

CA12, carbonic anhydrase 12 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CA12 分子靶点信息

  • 分子名：CA12, carbonic anhydrase 12
  • 别称：
    • CA-XII
    • carbonate dehydratase XII
    • carbonic anhydrase XII
    • carbonic dehydratase
    • CAXII
    • FLJ20151
    • HsT18816
    • T18816
    • tumor antigen HOM-RCC-3.1.3
  • 基因序列：NCBI_Gene: 771
  • 蛋白序列：UniProtKB: O43570

人 Human CA12靶点分子功能（预测）

Predicted to enable carbonate dehydratase activity. Involved in chloride ion homeostasis. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Implicated in isolated hyperchlorhidrosis.

小鼠 Mouse Car12 分子靶点信息

小鼠 Mouse Car12 靶点分子功能（预测）

Enables carbonate dehydratase activity. Predicted to be involved in chloride ion homeostasis and one-carbon metabolic process. Predicted to act upstream of or within carbon dioxide transport and regulation of pH. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in isolated hyperchlorhidrosis. Orthologous to human CA12 (carbonic anhydrase 12).

大鼠 Rat Ca12 分子靶点信息

  • 分子名：Ca12, carbonic anhydrase 12
  • 别称：
    • Car12
    • carbonic anyhydrase 12
    • LOC363085
    • membrane-bound carbonic anhydrase 12
  • 基因序列：NCBI_Gene: 363085
  • 蛋白序列：UniProtKB: A2IBE2

大鼠 Rat Ca12 靶点分子功能（预测）

Predicted to enable carbonate dehydratase activity. Predicted to be involved in chloride ion homeostasis and one-carbon metabolic process. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in isolated hyperchlorhidrosis. Orthologous to human CA12 (carbonic anhydrase 12).

CA12 分子产品列表

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