BMP7 靶点信息

BMP7 分子靶点信息概述

  • 分子名：BMP7, bone morphogenetic protein 7
  • 基因家族：Bone morphogenetic proteins
  • 别名：OP-1
  • 全称：osteogenic protein 1

BMP7 分子靶点综述

骨形态发生蛋白7(BMP-7)是TGF-β超家族成员，表达于大脑、肾脏和膀胱。它在间充质细胞转化为骨骼和软骨中具有关键作用。BMP-7诱导SMAD1和SMAD5磷酸化，反过来又可诱导成骨基因的转录。在很多类型的细胞中，BMP-7处理足以诱导成骨细胞分化的所有遗传标志。BMP-7有可能治疗慢性肾病。在对FSH治疗效果不好的不孕不育中，BMP-7注射可能可以作为一种治疗方式。BMP-7也可能用于人类肥胖症的治疗。

BMP7, bone morphogenetic protein 7 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human BMP7 分子靶点信息

人 Human BMP7靶点分子功能（预测）

Predicted to enable BMP receptor binding activity and cytokine activity. Involved in several processes, including regulation of gene expression; regulation of protein phosphorylation; and transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within negative regulation of neuron differentiation and neuron projection morphogenesis. Located in extracellular space. Implicated in prostate cancer. Biomarker of breast cancer; ovarian carcinoma; prostate cancer; and renal cell carcinoma.

小鼠 Mouse Bmp7 分子靶点信息

小鼠 Mouse Bmp7 靶点分子功能（预测）

Predicted to enable BMP receptor binding activity; cytokine activity; and heparin binding activity. Involved in several processes, including allantois development; animal organ development; and chordate embryonic development. Acts upstream of or within several processes, including embryonic morphogenesis; morphogenesis of a branching epithelium; and regulation of morphogenesis of a branching structure. Located in extracellular space. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Used to study obstructive sleep apnea and osteoarthritis. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human BMP7 (bone morphogenetic protein 7).

大鼠 Rat Bmp7 分子靶点信息

大鼠 Rat Bmp7 靶点分子功能（预测）

Enables heparin binding activity. Involved in several processes, including response to estradiol; response to peptide hormone; and response to vitamin D. Located in collagen-containing extracellular matrix; extracellular space; and vesicle. Biomarker of acute kidney tubular necrosis; kidney disease; nephroblastoma; and pyelonephritis. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human BMP7 (bone morphogenetic protein 7).

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