BMP2 靶点信息

BMP2 分子靶点信息概述

  • 分子名：BMP2, bone morphogenetic protein 2
  • 基因家族：Bone morphogenetic proteins
  • 别名：BMP2A

BMP2 分子靶点综述

骨形态发生蛋白2(BMP-2)属于TGF-β超家族蛋白。和其他的骨形态发生蛋白一样，BMP-2在骨和软骨的发育中起重要作用。BMP-2参与Hedgehog通路、TGF-β信号通路和细胞因子及其受体之间的相互作用，还参与心肌细胞分化和上皮细胞向间充质细胞转化。BMP-2和BMP-7都是骨诱导性的骨形态发生蛋白，实验表明他们可有效诱导许多细胞类型中成骨细胞的分化。在可吸收胶原海绵上使用双锥形螺纹融合器和重组人BMP-2可维持椎间脊柱的融合、提高临床疗效、减少患有退行性腰椎间盘疾病患者在前路腰椎椎间融合术后的疼痛。

BMP2, bone morphogenetic protein 2 分子靶点种属信息

人 Human大鼠 Rat

人 Human BMP2 分子靶点信息

  • 分子名：BMP2, bone morphogenetic protein 2
  • 别称：
    • BDA2
    • BMP-2A
    • BMP2A
    • bone morphogenetic protein 2A
    • SSFSC
    • SSFSC1
  • 基因序列：NCBI_Gene: 650
  • 蛋白序列：UniProtKB: P12643

人 Human BMP2靶点分子功能（预测）

Enables several functions, including BMP receptor binding activity; co-receptor binding activity; and phosphatase activator activity. Involved in several processes, including regulation of cellular biosynthetic process; regulation of signal transduction; and transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within several processes, including positive regulation of phosphate metabolic process; regulation of transcription by RNA polymerase II; and regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Located in cell surface; extracellular space; and intracellular membrane-bounded organelle. Part of BMP receptor complex. Implicated in bone disease (multiple); hemochromatosis type 1; otosclerosis; prostate cancer; and tooth agenesis. Biomarker of prostate cancer and prostate carcinoma.

大鼠 Rat Bmp2 分子靶点信息

大鼠 Rat Grem2 靶点分子功能（预测）

Enables cytokine activity; phosphatase activator activity; and protein serine/threonine kinase activator activity. Involved in several processes, including animal organ development; cardiac jelly development; and positive regulation of extracellular matrix constituent secretion. Acts upstream of or within several processes, including animal organ development; positive regulation of cell differentiation; and regulation of odontogenesis. Located in extracellular space and nucleus. Is active in extracellular region and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and limb. Human ortholog(s) of this gene implicated in bone disease (multiple); hemochromatosis type 1; otosclerosis; prostate cancer; and tooth agenesis. Orthologous to human BMP2 (bone morphogenetic protein 2).

GREM2 分子产品列表

GREM2 分子靶点最新资讯

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