B4GALT1 靶点信息

B4GALT1 分子靶点信息概述

  • 分子名：B4GALT1, beta-1,4-galactosyltransferase 1
  • 基因家族：Beta 4-glycosyltransferases
  • 别名：beta4Gal-T1
  • 曾用名：GGTB2
  • 全称：UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1

B4GALT1 分子靶点综述

β-1,4-半乳糖基转移酶1(B4GALT1)，是7种β-1,4-半乳糖基转移酶中的一种，通常存在于反式高尔基复合体中，可将半乳糖转移至寡糖。根据序列相似性，B4GALTs可分为4组：B4GALT1和B4GALT2，B4GALT3和B4GALT4，B4GALT5和B4GALT6以及B4GALT7。这7种酶中，B4GALT1是独特的，因为它可作为膜结合形式或者分泌形式表达。分泌型只存在于哺乳期乳腺组织中，在这里，该酶和α-乳白蛋白形成一个异源二聚体，进而催化乳糖的合成。膜结合型要么存在于高尔基体中，在这里，该酶添加半乳糖至N-乙酰葡糖胺残基，要么存在于细胞表面，在多种细胞与细胞、细胞与基质的相互作用过程中，该酶通过结合到对立细胞或细胞外基质的特定寡糖配体上，作为一个识别分子发挥作用。这两种酶形式产生于交替的转录起始位点和翻译后加工。B4GALT1缺失会导致2D型糖基化的先天失常。

B4GALT1, beta-1,4-galactosyltransferase 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human B4GALT1 分子靶点信息

  • 分子名：B4GALT1, beta-1,4-galactosyltransferase 1
  • 别称：
    • B4GAL-T1
    • beta-1,4-GalTase 1
    • beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
    • beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
    • beta4Gal-T1
    • CDG2D
    • DKFZp686N19253
    • GGTB2
    • glycoprotein-4-beta-galactosyltransferase 2
    • GT1
    • GTB
    • lactose synthase
    • MGC50983
    • N-acetyllactosamine synthase
    • nal synthase
    • neolactotriaosylceramide beta-1,4-galactosyltransferase
    • UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1
    • UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
    • UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1
  • 基因序列：NCBI_Gene: 2683
  • 蛋白序列：UniProtKB: P15291

人 Human B4GALT1靶点分子功能（预测）

Enables several functions, including UDP-galactosyltransferase activity; manganese ion binding activity; and tubulin binding activity. Involved in oligosaccharide biosynthetic process and protein N-linked glycosylation. Located in several cellular components, including Golgi trans cisterna; basolateral plasma membrane; and brush border membrane. Implicated in congenital disorder of glycosylation and congenital disorder of glycosylation type IId.

小鼠 Mouse B4galt1 分子靶点信息

小鼠 Mouse B4galt1 靶点分子功能（预测）

Enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; cytoskeletal protein binding activity; and laminin binding activity involved in cell-matrix adhesion. Involved in cell-matrix adhesion. Acts upstream of or within several processes, including lactose biosynthetic process; single fertilization; and tube morphogenesis. Located in Golgi apparatus; cell surface; and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; liver; and nervous system. Used to study IgA glomerulonephritis and endocrine system disease. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and congenital disorder of glycosylation type IId. Orthologous to human B4GALT1 (beta-1,4-galactosyltransferase 1).

大鼠 Rat B4galt1 分子靶点信息

  • 分子名：B4galt1, beta-1,4-galactosyltransferase 1
  • 别称：
    • b4Gal-T1
    • B4galt1_mapped
    • beta-1,4-GalTase 1
    • beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
    • beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
    • beta4Gal-T1
    • Ggtb2
    • Glycoprotein-4-beta-galactosyltransferase 2
    • N-acetyllactosamine synthase
    • nal synthase
    • neolactotriaosylceramide beta-1,4-galactosyltransferase
    • UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1
    • UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
    • UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (mapped)
    • UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1
  • 基因序列：NCBI_Gene: 24390
  • 蛋白序列：

大鼠 Rat B4galt1 靶点分子功能（预测）

Predicted to enable several functions, including UDP-galactosyltransferase activity; laminin binding activity involved in cell-matrix adhesion; and tubulin binding activity. Involved in response to wounding. Predicted to be located in several cellular components, including Golgi trans cisterna; basolateral plasma membrane; and brush border membrane. Predicted to be active in Golgi apparatus and plasma membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and congenital disorder of glycosylation type IId. Orthologous to human B4GALT1 (beta-1,4-galactosyltransferase 1).

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