ARG1 靶点信息

ARG1 分子靶点信息概述

  • 分子名：ARG1, arginase 1
  • 全称：arginase-1; arginase, liver

ARG1 分子靶点综述

精氨酸酶是尿素循环的关键元素，催化L-精氨酸生成尿素和L-鸟氨酸，进而促进胶原合成和细胞增殖。精氨酸代谢是先天性和适应性免疫反应的关键调节因子，参与多形核粒细胞(PMN)的抗菌效应途径。在PMN凋亡过程中，微环境中的精氨酸被耗尽，会抑制T细胞和自然杀伤细胞的增殖和细胞因子的分泌。精氨酸酶1(ARG1)是精氨酸酶家族中的一个成员，分子量35 - 40 kDa。它表达于多种类型细胞，包括红细胞、肝细胞、中性粒细胞、平滑肌和巨噬细胞。人AGR1的长度为322个氨基酸(aa)。其酶区由9 - 309位氨基酸组成，含有两个Mn原子。ARG1单体具有中等活性，但作为105kDa的同型三聚体，是具有高活性的。

ARG1, arginase 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human ARG1 分子靶点信息

  • 分子名：ARG1, arginase 1
  • 别称：
    • arginase-1
    • arginase, liver
    • liver-type arginase
    • type I arginase
  • 基因序列：NCBI_Gene: 383
  • 蛋白序列：UniProtKB: P05089

人 Human ARG1靶点分子功能（预测）

Predicted to enable arginase activity and manganese ion binding activity. Involved in negative regulation of T cell proliferation; negative regulation of interferon-gamma-mediated signaling pathway; and positive regulation of neutrophil mediated killing of fungus. Located in extracellular space. Implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Biomarker of asthma and colitis.

小鼠 Mouse Arg1 分子靶点信息

小鼠 Mouse Arg1 靶点分子功能（预测）

Enables arginase activity. Involved in defense response to protozoan; negative regulation of T-helper 2 cell cytokine production; and negative regulation of activated T cell proliferation. Predicted to be located in several cellular components, including extracellular space; mitochondrial outer membrane; and neuronal cell body. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study hyperargininemia. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1).

大鼠 Rat Arg1 分子靶点信息

  • 分子名：Arg1, arginase 1
  • 别称：
    • AI type I arginase
    • AI, type I arginase
    • arginase 1 liver
    • Arginase 1, liver
    • arginase-1
    • arginase, liver
    • liver-type arginase
    • type I arginase
  • 基因序列：NCBI_Gene: 29221
  • 蛋白序列：UniProtKB: P07824

大鼠 Rat Arg1 靶点分子功能（预测）

Enables arginase activity; identical protein binding activity; and manganese ion binding activity. Involved in several processes, including cellular response to hormone stimulus; gland development; and response to vitamin. Located in several cellular components, including extracellular space; mitochondrial outer membrane; and neuronal cell body. Used to study acute necrotizing pancreatitis and hypertension. Biomarker of several diseases, including acute kidney failure; cholestasis; silicosis; ureteral obstruction; and uveitis. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1).

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