AREG 靶点信息

AREG 分子靶点信息概述

  • 分子名：AREG, amphiregulin
  • 基因家族：Receptor ligands
  • 曾用名：SDGF, AREGB, AR, CRDGF
  • 全称：schwannoma-derived growth factor, amphiregulin B, Colorectum Cell-Derived Growth Factor

AREG 分子靶点综述

双调蛋白（Amphiregulin，AREG），是一种表皮生长因子，属于EGF家族。
该家族还包括 TGF - α、HB - EGF、β细胞素 ( BTC )、上皮调节蛋白、神经调节蛋白类。人 Amphiregulin 是一种分子量约为 50 kDa 的跨膜糖蛋白，由 252 个氨基酸组成的跨膜糖蛋白，包含一个由 81 个氨基酸组成的 N 端前肽、一个肝素结合域、一个 EGF 样结构域、一个由 23 个氨基酸组成的跨膜域和一个由 31 个氨基酸组成的胞浆域。AREG 基因的表达和释放是由炎性脂质、细胞因子、激素、生长因子和外源性药物等多种刺激引起的，与 EGFR 结合，AREG 激活细胞内信号的产生，调节不同类型的细胞增殖、凋亡和迁移，包括上皮细胞、成纤维细胞和免疫细胞 (树突状细胞、中性粒细胞、肥大细胞和淋巴细胞)。AREG 在肺形态发生和乳腺、骨组织和卵母细胞的发育成熟中发挥重要作用。AREG 在感染或损伤后的组织完整性恢复中也发挥着关键作用。

AREG, amphiregulin 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human AREG 分子靶点信息

  • 分子名：AREG, amphiregulin
  • 别称：
    • amphiregulin B
    • AR
    • AREGB
    • colorectum cell-derived growth factor
    • CRDGF
    • MGC13647
    • schwannoma-derived growth factor
    • SDGF
  • 基因序列：NCBI_Gene: 374
  • 蛋白序列：UniProtKB: P15514

人 Human AREG靶点分子功能（预测）

Enables receptor ligand activity and transmembrane receptor protein tyrosine kinase activator activity. Involved in ERBB2-EGFR signaling pathway; G protein-coupled receptor signaling pathway; and positive regulation of cell population proliferation. Located in cell surface. Is active in extracellular space. Implicated in breast cancer. Biomarker of ductal carcinoma in situ; invasive ductal carcinoma; prostate carcinoma in situ; transitional cell carcinoma; and urinary bladder cancer.

小鼠 Mouse Areg 分子靶点信息

小鼠 Mouse Areg 靶点分子功能（预测）

Enables receptor ligand activity and transmembrane receptor protein tyrosine kinase activator activity. Involved in epidermal growth factor receptor signaling pathway. Acts upstream of or within several processes, including mammary gland development; positive regulation of peptidyl-tyrosine phosphorylation; and response to estradiol. Located in cytoplasm and nucleus. Is active in extracellular space. Is expressed in several structures, including alimentary system; heart; lung; metanephros; and submandibular gland primordium. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human AREG (amphiregulin).

大鼠 Rat Areg 分子靶点信息

大鼠 Rat Areg 靶点分子功能（预测）

Enables epidermal growth factor receptor binding activity and growth factor activity. Involved in several processes, including negative regulation of osteoblast differentiation; neurogenesis; and response to hydrogen peroxide. Located in extracellular space. Used to study high grade glioma. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human AREG (amphiregulin).

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