APOH 靶点信息

APOH 分子靶点信息概述

  • 分子名：APOH, apolipoprotein H
  • 基因家族：Apolipoproteins; Sushi domain containing
  • 别名：BG
  • 曾用名：B2G1
  • 全称：beta-2-glycoprotein I; apolipoprotein H (beta-2-glycoprotein I)

APOH 分子靶点综述

载脂蛋白H(ApoH)，又称为β2糖蛋白I，是一个多功能载脂蛋白，在人类中由APOH基因编码。它是一种由肝细胞合成的糖蛋白，功能之一是结合磷脂。ApoH可结合到多种带负电荷的物质上，如肝素、磷脂和硫酸葡聚糖。ApoH参与凝集过程很复杂，可改变ADP介导的血小板凝集。它与受损细胞表面的磷脂结合，进而阻止先天性凝血级联的激活。通常，血清中的ApoH呈现出抗凝血活性(通过抑制凝血因子)。它的血浆浓度与代谢综合征的改变和2型糖尿病的血管病变密切相关，被作为评估心血管风险的临床指标。

APOH, apolipoprotein H 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human APOH 分子靶点信息

  • 分子名：APOH, apolipoprotein H
  • 别称：
    • activated protein C-binding protein
    • anticardiolipin cofactor
    • APC inhibitor
    • apo-H
    • apolipoprotein H (beta-2-glycoprotein I)
    • B2G1
    • B2GP1
    • B2GPI
    • beta-2-glycoprotein 1
    • beta(2)GPI
    • BG
  • 基因序列：NCBI_Gene: 350
  • 蛋白序列：UniProtKB: P02749

人 Human APOH靶点分子功能（预测）

Enables identical protein binding activity; lipoprotein lipase activator activity; and phospholipid binding activity. Involved in several processes, including blood coagulation, intrinsic pathway; negative regulation of apoptotic process; and regulation of blood coagulation. Located in cell surface and extracellular space. Part of chylomicron; high-density lipoprotein particle; and very-low-density lipoprotein particle. Colocalizes with collagen-containing extracellular matrix. Implicated in antiphospholipid syndrome; myocardial infarction; and peripheral vascular disease. Biomarker of arteriosclerosis; diabetes mellitus; diabetic retinopathy; macular retinal edema; and type 2 diabetes mellitus.

小鼠 Mouse Apoh 分子靶点信息

小鼠 Mouse Apoh 靶点分子功能（预测）

Predicted to enable identical protein binding activity; lipoprotein lipase activator activity; and phospholipid binding activity. Acts upstream of or within regulation of blood coagulation. Located in extracellular space. Is expressed in liver lobe and lung. Human ortholog(s) of this gene implicated in antiphospholipid syndrome; myocardial infarction; and peripheral vascular disease. Orthologous to human APOH (apolipoprotein H).

大鼠 Rat Apoh 分子靶点信息

大鼠 Rat Apoh 靶点分子功能（预测）

Enables lipid binding activity. Involved in several processes, including negative regulation of respiratory burst; positive regulation of triglyceride catabolic process; and triglyceride transport. Located in several cellular components, including cell surface; extracellular space; and plasma membrane. Used to study myocardial infarction and thrombosis. Human ortholog(s) of this gene implicated in antiphospholipid syndrome; myocardial infarction; and peripheral vascular disease. Orthologous to human APOH (apolipoprotein H).

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