APOD 靶点信息

APOD 分子靶点信息概述

  • 分子名：APOD, apolipoprotein D
  • 基因家族：Apolipoproteins; Lipocalins
  • 别名：Apo-D

APOD 分子靶点综述

载脂蛋白D (Apo D)是一个分子量约为33 kDa的糖蛋白，在人类中由APOD基因编码。不同于其它主要在肝脏中产生的脂蛋白，Apo D主要产生于大脑和睾丸。它是高密度脂蛋白(HDL)的一个组分，与其它载脂蛋白序列没有显著的相似性。Apo D与卵磷脂：胆固醇酰基转移酶密切相关，后者参与脂蛋白代谢。Apo D同样是HDL和LDL颗粒之间、HDL颗粒和细胞之间短暂相互作用的一个重要连接。Apo D是雄激素不敏感综合征(AIS)的生物标志物，它与神经紊乱、神经损伤有关，尤其是髓鞘。中风的大鼠模型中，其Apo D水平是升高的。精神分裂症、双相障碍和阿尔茨海默病患者的Apo D水平是升高的。

APOD, apolipoprotein D 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human APOD 分子靶点信息

人 Human APOD靶点分子功能（预测）

Enables cholesterol binding activity. Involved in several processes, including negative regulation of cell-matrix adhesion; negative regulation of macromolecule metabolic process; and negative regulation of protein import into nucleus. Located in extracellular space and perinuclear region of cytoplasm. Implicated in obesity and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; gestational diabetes; and type 2 diabetes mellitus.

小鼠 Mouse Apod 分子靶点信息

小鼠 Mouse Apod 靶点分子功能（预测）

Predicted to enable cholesterol binding activity. Involved in negative regulation of lipoprotein lipid oxidation and response to reactive oxygen species. Predicted to be located in several cellular components, including cytosolic ribosome; neuronal cell body; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; embryo mesenchyme; lip; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human APOD (apolipoprotein D).

大鼠 Rat Apod 分子靶点信息

大鼠 Rat Apod 靶点分子功能（预测）

Predicted to enable cholesterol binding activity. Involved in several processes, including aging; nervous system development; and tissue regeneration. Located in several cellular components, including cytosolic ribosome; dendrite; and neuronal cell body. Biomarker of status epilepticus and vasculogenic impotence. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human APOD (apolipoprotein D).

APOD 分子产品列表

APOD 分子靶点最新资讯

联科生物：Human Apo D ELISA 检测试剂盒