APOB 靶点信息

APOB 分子靶点信息概述

  • 分子名：APOB, apolipoprotein B
  • 基因家族：Apolipoproteins
  • 全称：apolipoprotein B (including Ag(x) antigen)

APOB 分子靶点综述

Apo B是乳糜微粒、极低密度脂蛋白(VLDL)、中密度脂蛋白(IDL)和低密度脂蛋白(LDL)颗粒的主要载脂蛋白，负责运输脂肪分子(脂质)。由于氨基酸组成的差异，Apo B可分为Apo B48和Apo B100两个亚类。高水平的Apo B，尤其是和高浓度LDL一起，是引起血管疾病(动脉粥样硬化)的主要驱动力。肝脏中过量的Apo B引起脂质诱导的内质网应激和胰岛素抵抗。研究表明，相对于单独测定Apo B-100或Apo A1，Apo B-100/Apo A1比率可更有效地预测急性心肌梗死患者的心脏病发作的风险。

APOB, apolipoprotein B 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human APOB 分子靶点信息

  • 分子名：APOB, apolipoprotein B
  • 别称：
    • apo B-100
    • apoB-100
    • apoB-48
    • apolipoprotein B (including Ag(x) antigen)
    • apolipoprotein B-100
    • apolipoprotein B48
    • FCHL2
    • FLDB
    • LDLCQ4
    • mutant Apo B 100
  • 基因序列：NCBI_Gene: 338
  • 蛋白序列：UniProtKB: P04114

人 Human APOB靶点分子功能（预测）

Enables several functions, including cholesterol transfer activity; heparin binding activity; and lipase binding activity. Involved in several processes, including cholesterol homeostasis; low-density lipoprotein particle clearance; and low-density lipoprotein particle remodeling. Located in cytosol; endoplasmic reticulum exit site; and neuronal cell body. Part of low-density lipoprotein particle; mature chylomicron; and triglyceride-rich plasma lipoprotein particle. Implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Biomarker of several diseases, including common bile duct neoplasm; diabetes mellitus (multiple); familial combined hyperlipidemia; hypobetalipoproteinemia; and obesity.

小鼠 Mouse Apob 分子靶点信息

小鼠 Mouse Apob 靶点分子功能（预测）

Predicted to enable several functions, including cholesterol transfer activity; heparin binding activity; and lipase binding activity. Acts upstream of or within several processes, including cholesterol efflux; lipoprotein metabolic process; and triglyceride metabolic process. Located in endoplasmic reticulum. Is expressed in several structures, including adrenal gland; brain; extraembryonic component; genitourinary system; and gut. Used to study familial hypobetalipoproteinemia 2. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Orthologous to human APOB (apolipoprotein B).

大鼠 Rat Apob 分子靶点信息

大鼠 Rat Apob 靶点分子功能（预测）

Predicted to enable several functions, including cholesterol transfer activity; heparin binding activity; and lipase binding activity. Involved in several processes, including cellular response to tumor necrosis factor; response to estradiol; and triglyceride catabolic process. Located in several cellular components, including extracellular space; vesicle lumen; and vesicle membrane. Part of high-density lipoprotein particle; low-density lipoprotein particle; and very-low-density lipoprotein particle. Biomarker of fatty liver disease and nephrotic syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Orthologous to human APOB (apolipoprotein B).

APOB 分子产品列表

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