ANGPT2 靶点信息

ANGPT2 分子靶点信息概述

  • 分子名：ANGPT2, angiopoietin 2
  • 基因家族：Receptor ligands; Fibrinogen C domain containing
  • 别名：Ang2

ANGPT2 分子靶点综述

血管生成素-2(ANG-2)是一个分子量约为70kDa的分泌型糖蛋白，在血管生成、炎症和血管发育中起复杂作用，在高度血管生成组织的血管内皮细胞和平滑肌细胞、肺上皮细胞、分化的肌管、神经祖细胞中表达。ANG-2促进内皮细胞的生存、增殖和迁移，并促进出芽式血管生成，它诱导血管壁周细胞的损失，增加血管通透性。ANG-2对于淋巴管的发育、淋巴管和血管的后天重塑是必不可少的。血管肉瘤患者的ANG-2水平是升高的，研究表明，ANG-2参与感染性休克的发病。血清中ANG-2的表达与多发性骨髓瘤的生长、血管生成和口腔鳞状细胞癌的整体存活有关。循环的ANG-2是慢性透析的儿童早期心血管疾病的一个标志，卡波氏肉瘤相关疱疹病毒引起内皮细胞快速释放出ANG-2。

ANGPT2, angiopoietin 2 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human ANGPT2 分子靶点信息

  • 分子名：ANGPT2, angiopoietin 2
  • 别称：
    • AGPT2
    • ANG-2
    • ANG2
    • angiopoietin-2
    • angiopoietin-2a
    • angiopoietin-2B
    • LMPHM10
    • Tie2-ligand
  • 基因序列：NCBI_Gene: 285
  • 蛋白序列：UniProtKB: O15123

人 Human ANGPT2靶点分子功能（预测）

Enables receptor tyrosine kinase binding activity. Involved in Tie signaling pathway; negative regulation of blood vessel endothelial cell migration; and negative regulation of positive chemotaxis. Acts upstream of or within gene expression. Located in extracellular space. Implicated in hereditary lymphedema. Biomarker of COVID-19; endometrial adenocarcinoma; transitional cell carcinoma; and type 2 diabetes mellitus.

小鼠 Mouse Angpt2 分子靶点信息

小鼠 Mouse Angpt2 靶点分子功能（预测）

Predicted to enable receptor tyrosine kinase binding activity. Acts upstream of or within angiogenesis; negative regulation of angiogenesis; and negative regulation of cell-substrate adhesion. Located in extracellular space. Is expressed in several structures, including cardiovascular system; central nervous system; hemolymphoid system; limb interdigital region; and urinary system. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human ANGPT2 (angiopoietin 2).

大鼠 Rat Angpt2 分子靶点信息

大鼠 Rat Angpt2 靶点分子功能（预测）

Predicted to enable receptor tyrosine kinase binding activity. Involved in several processes, including blood vessel development; maternal process involved in female pregnancy; and positive regulation of angiogenesis. Located in several cellular components, including extracellular space; nucleus; and plasma membrane. Used to study several diseases, including ischemia (multiple); membranoproliferative glomerulonephritis; portal hypertension; retinal disease (multiple); and uremia. Biomarker of several diseases, including Caroli disease; artery disease (multiple); glomerulonephritis (multiple); musculoskeletal system cancer (multiple); and retinal disease (multiple). Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human ANGPT2 (angiopoietin 2).

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