AHSG 靶点信息

AHSG 分子靶点信息概述

  • 分子名：AHSG, alpha 2-HS glycoprotein
  • 基因家族：Cystatins, type 4
  • 别名：FETUA; A2HS; HSGA
  • 全称：fetuin A

AHSG 分子靶点综述

胎球蛋白是由肝脏产生，分泌到血液中的蛋白。它们属于介导血液中各种物质的转运和利用的结合蛋白。人胎球蛋白也称为α2-HS糖蛋白(AHSG)、α2-HS、A2HS、AHS、HSGA和胎球蛋白A。基因敲除小鼠的实验表明，胎球蛋白A是潜在的全身性钙化抑制剂。它对肝脏中游离脂肪酸诱导的胰岛素耐受具有重要作用。在糖尿病前期，胎球蛋白A可预测不良血糖的结果。它也与非酒精性脂肪肝和心血管疾病发病率升高有关。在脓毒病和内毒素血症中，它是负性急性期反应物，促进伤口愈合，对阿尔茨海默病具有神经保护作用。在阻塞性肺疾病、克罗恩病和溃疡性结肠炎中，胎球蛋白A水平下降，预示着疾病活跃的风险增加。

AHSG, alpha 2-HS glycoprotein 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human AHSG 分子靶点信息

  • 分子名：AHSG, alpha 2-HS glycoprotein
  • 别称：
    • A2HS
    • AHS
    • alpha-2-HS-glycoprotein
    • alpha-2-Z-globulin
    • APMR1
    • ba-alpha-2-glycoprotein
    • FETUA
    • fetuin A
    • fetuin-A
    • HSGA
  • 基因序列：NCBI_Gene: 197
  • 蛋白序列：UniProtKB: P02765

人 Human AHSG靶点分子功能（预测）

Predicted to enable endopeptidase inhibitor activity. Involved in acute-phase response; positive regulation of phagocytosis; and regulation of inflammatory response. Located in Golgi apparatus. Implicated in alopecia-mental retardation syndrome 1; coronary artery disease; and type 2 diabetes mellitus. Biomarker of gestational diabetes; myocardial infarction; obesity; and type 2 diabetes mellitus.

小鼠 Mouse Ahsg 分子靶点信息

小鼠 Mouse Ahsg 靶点分子功能（预测）

Predicted to enable endopeptidase inhibitor activity and receptor signaling protein tyrosine kinase inhibitor activity. Involved in negative regulation of bone mineralization. Acts upstream of or within ossification. Predicted to be located in Golgi apparatus; collagen-containing extracellular matrix; and extracellular space. Predicted to be part of protein-containing complex. Predicted to be active in extracellular matrix and extracellular region. Is expressed in several structures, including gut; heart; limb segment; reproductive system; and skeletal musculature. Human ortholog(s) of this gene implicated in alopecia-mental retardation syndrome 1; coronary artery disease; and type 2 diabetes mellitus. Orthologous to human AHSG (alpha 2-HS glycoprotein).

大鼠 Rat Ahsg 分子靶点信息

  • 分子名：Ahsg, alpha-2-HS-glycoprotein
  • 别称：
    • 59 kDa bone sialic acid-containing protein
    • Aa2-066
    • alpha 2 HS-glycoprotein alpha 2 (fetuin)
    • BSP
    • fetuin-A
    • glycoprotein PP63
    • phosphorylated N-glycoprotein pp63
    • phosphorylated N-glycoprotein, pp63
    • pp63
  • 基因序列：NCBI_Gene: 25373
  • 蛋白序列：UniProtKB: P24090

大鼠 Rat Ahsg 靶点分子功能（预测）

Enables receptor signaling protein tyrosine kinase inhibitor activity. Involved in several processes, including animal organ development; negative regulation of bone mineralization; and positive regulation of bone resorption. Located in collagen-containing extracellular matrix and extracellular space. Part of protein-containing complex. Human ortholog(s) of this gene implicated in alopecia-mental retardation syndrome 1; coronary artery disease; and type 2 diabetes mellitus. Orthologous to human AHSG (alpha 2-HS glycoprotein).

AHSG 分子产品列表

AHSG 分子靶点最新资讯

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