AFP 靶点信息

AFP 分子靶点信息概述

  • 分子名：AFP, alpha fetoprotein
  • 别名：FETA
  • 曾用名：HPAFP
  • 全称：alpha-fetoprotein

AFP 分子靶点综述

甲胎蛋白(AFP)是胚胎发育中由卵黄囊和肝脏产生的最主要的血浆蛋白。出生后其在血浆中的含量迅速下降，但在产前3个月已开始下降。通常在8-12个月后达到正常成人水平。通过母血或羊水测定孕妇的AFP含量，用于排查筛选异常发育。AFP在一些疾病中表达升高，包括脐疝、原发性肝细胞肝癌、神经管畸形、非精原细胞瘤、卵黄囊瘤和共济失调毛细血管扩张症等。

AFP, alpha fetoprotein 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human AFP 分子靶点信息

  • 分子名：AFP, alpha fetoprotein
  • 别称：
    • AFPD
    • alpha-1-fetoprotein
    • alpha-fetoglobulin
    • alpha-fetoprotein
    • FETA
    • HPAFP
  • 基因序列：NCBI_Gene: 174
  • 蛋白序列：UniProtKB: P02771

人 Human AFP靶点分子功能（预测）

Predicted to enable fatty acid binding activity and zinc ion binding activity. Predicted to act upstream of or within SMAD protein signal transduction; ovulation from ovarian follicle; and progesterone metabolic process. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in cytoplasm. Implicated in hepatitis C. Biomarker of carcinoma (multiple); germ cell cancer (multiple); and reproductive organ cancer (multiple).

小鼠 Mouse Afp 分子靶点信息

小鼠 Mouse Afp 靶点分子功能（预测）

Predicted to enable fatty acid binding activity and zinc ion binding activity. Acts upstream of or within SMAD protein signal transduction; ovulation from ovarian follicle; and progesterone metabolic process. Located in cytoplasm and extracellular space. Is expressed in several structures, including amniotic fluid; egg cylinder; gut; liver and biliary system; and metanephros. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human AFP (alpha fetoprotein).

大鼠 Rat Afp 分子靶点信息

大鼠 Rat Afp 靶点分子功能（预测）

Predicted to enable fatty acid binding activity and zinc ion binding activity. Involved in several processes, including cellular response to retinoic acid; liver regeneration; and response to dexamethasone. Located in cytosol and extracellular space. Biomarker of hepatitis. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human AFP (alpha fetoprotein).

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