CD8A 靶点信息

文章目录[隐藏]

CD8A 分子靶点信息概述

  • 分子名：CD8A, CD8a molecule
  • 基因家族：CD molecules; V-set domain containing
  • 曾用名：CD8
  • 全称：CD8 antigen, alpha polypeptide (p32); T-cell surface glycoprotein CD8 alpha chain

CD8A 分子靶点综述

CD8也称为T8或Leu2，是免疫球蛋白超家族的一员，表达于大部分胸腺细胞、外周血T细胞亚群和NK细胞(基本为CD8α/α同源二聚体)。CD8在抗原识别和T细胞活化中，作为MHC I类分子受限的T细胞受体，并在胸腺分化中具有重要作用。

CD8A, CD8a molecule 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CD8A 分子靶点信息

  • 分子名：CD8A, CD8a molecule
  • 别称：
    • CD8
    • cd8 antigen, alpha chain
    • CD8 antigen, alpha polypeptide (p32)
    • Cluster of Differentiation 8a
    • Leu2
    • Leu2 T-lymphocyte antigen
    • MAL
    • OKT8 T-cell antigen
    • p32
    • T cell co-receptor
    • T-cell antigen Leu2
    • T-cell surface glycoprotein CD8 alpha chain
    • T-lymphocyte differentiation antigen T8/Leu-2
    • T8 T-cell antigen
  • 基因序列：NCBI_Gene: 925
  • 蛋白序列：UniProtKB: P01732

人 Human CD8A靶点分子功能（预测）

Enables MHC class I protein complex binding activity. Predicted to be involved in T cell mediated immunity; cell surface receptor signaling pathway; and cytotoxic T cell differentiation. Predicted to act upstream of or within defense response to virus and positive regulation of calcium-mediated signaling. Located in external side of plasma membrane and plasma membrane raft. Biomarker of COVID-19; erythema multiforme; and stomach cancer.

小鼠 Mouse Cd8a 分子靶点信息

小鼠 Mouse Cd8a 靶点分子功能（预测）

Enables identical protein binding activity. Acts upstream of or within several processes, including cytotoxic T cell differentiation; defense response to virus; and positive regulation of calcium-mediated signaling. Located in external side of plasma membrane. Is expressed in several structures, including endocrine gland; exocrine gland; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human CD8A (CD8a molecule).

大鼠 Rat Cd8a 分子靶点信息

  • 分子名：Cd8a, CD8a molecule
  • 别称：
    • CD8 antigen 32 kDa chain
    • CD8 antigen alpha-chain
    • CD8 antigen, alpha chain
    • CD8 antigen, alpha-chain
    • OX-8 membrane antigen
    • T-cell surface glycoprotein CD8 alpha chain
  • 基因序列：NCBI_Gene: 24930
  • 蛋白序列：UniProtKB: P07725

大鼠 Rat Cd8a 靶点分子功能（预测）

Enables protein kinase binding activity. Involved in T cell activation. Predicted to be located in cell surface and plasma membrane raft. Predicted to be active in external side of plasma membrane. Orthologous to human CD8A (CD8a molecule).

CD8A 分子产品列表

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