P201B

Recombinant Mouse IL-1 beta

¥700.00 – ¥2,500.00

说明书

分子靶点：IL1B, IL1-β, IL1F2
种属：小鼠 (Mouse)
表达宿主：Escherichia coli
纯度：≥95% as determined by SDS-PAGE
内毒素：<1EU/ug

在售SKU: P201B, 70-P201B-10, 70-P201B-100, 70-P201B-50

描述

文章目录[隐藏]

General Information
Specifications
Data
分子信息
IL1B 分子靶点信息概述
IL1B 分子靶点综述
- 小鼠 Mouse Il1b 分子靶点信息
- 小鼠 Mouse Il1b 靶点分子功能（预测）

General Information

Source	Escherichia coli
Synonyms	Interleukin 1 beta; IL1F2; IL-1B; IL1-BETA
Accession	P10749
Molecular Mass	17.5 KDa
Description	Recombinant Mouse IL-1 beta is an 17.5 kDa protein consisting of 153 amino acid residues.
Shipping	The product is shipped at 4 ℃ . Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Aliquot the reconstituted solution to minimize freeze-thaw cycles. Lyophilized protein should be stored at -20℃ to -80℃, stable for one year after receipt. Aliquots of reconstituted samples are stable at ≤ -20℃ for 3 months.
Reconstitution	Centrifuge tubes before opening. Dissolve the lyophilized protein in distilled water. Do not mix by vortex. It is recommended to dissolve the product at a concentration of twice the specified specification.
Background	Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury.

Specifications

Formulation	Lyophilized from sterile PBS, pH 7.4, 5% trehalose.
Purity	≥95% as determined by SDS-PAGE
Endotoxin	<1EU/ug
Bio Activity	Immobilized Anti-Mouse IL-1B Antibody at 0.2 ug/mL (50 uL/well) can bind Mouse IL-1B with a linear range of 48.83 - 25,000 pg/mL.

Data

Greater than 95% as determined by reducing SDS-PAGE.

Bioactivity — Immobilized Anti-Mouse IL-1B Antibody at 0.2 ug/mL (50 uL/well) can bind Mouse IL-1B with a linear range of 48.83 - 25,000 pg/mL. (EC50 = 1.17 ng/mL)

分子信息

概述小鼠 IL1B, IL1-β, IL1F2 靶点信息

IL1B 分子靶点信息概述

分子名：IL1B, interleukin 1 beta
基因家族：Interleukins
别名：IL1F2; IL-1B; IL1-BETA

IL1B 分子靶点综述

白细胞介素1(IL-1)是17kDa的胞外多肽，分为IL-1α和IL-1β两种蛋白。IL-1β是活化的巨噬细胞分泌的蛋白前体，通过caspase1(CASP1/ICE)水解产生的活化形式。该细胞因子是炎症反应的重要介导者，参与许多细胞活性，包括细胞增殖、分化和凋亡。IL-1是一类重要的蛋白家族，它们由生物活化的单核细胞所衍生，参与炎症反应和免疫应答。IL-1β表达升高会产生各种不同的自身炎症综合征，最显著的是单基因条件称为CAPS，是由于触发IL-1β加工的炎性体受体NLRP3发生突变而引起的。本试剂盒用来检测人IL-1β的成熟形式和未裂解的前体形式。

小鼠 Mouse Il1b 分子靶点信息

分子名：Il1b, interleukin 1 beta
别称：
- IL-1B
- Il-1b
- IL-1beta
基因序列：NCBI_Gene: 16176
蛋白序列：
- UniprotKB: P10749
- UniprotKB: Q3TI17

小鼠 Mouse Il1b 靶点分子功能（预测）

Enables cytokine activity. Involved in several processes, including negative regulation of cell communication; regulation of defense response; and regulation of lipid metabolic process. Acts upstream of or within several processes, including ectopic germ cell programmed cell death; positive regulation of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Located in extracellular space and secretory granule. Is expressed in several structures, including dorsal aorta; early conceptus; hemolymphoid system; integument; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); blood platelet disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Orthologous to human IL1B (interleukin 1 beta).