P202

Recombinant Mouse IL-2

¥500.00 – ¥2,000.00

说明书

分子靶点：IL2, IL-2
种属：小鼠 (Mouse)
表达宿主：Escherichia coli
纯度：≥95% as determined by SDS-PAGE
内毒素：<1EU/ug

在售SKU: P202, 70-P202-10, 70-P202-100, 70-P202-50

描述

文章目录[隐藏]

General Information
Specifications
Data
分子信息
IL2 分子靶点信息概述
IL2 分子靶点综述
- 小鼠 Mouse Il2 分子靶点信息
- 小鼠 Mouse Il2 靶点分子功能（预测）

General Information

Source	Escherichia coli
Synonyms	Interleukin 2;IL2; TCGF
Accession	P04351
Molecular Mass	17.2 KDa
Description	Recombinant Mouse IL-2 is an 17.2 kDa protein consisting of 148 amino acid residues.
Shipping	The product is shipped at 4 ℃ . Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Aliquot the reconstituted solution to minimize freeze-thaw cycles. Lyophilized protein should be stored at -20℃ to -80℃, stable for one year after receipt. Aliquots of reconstituted samples are stable at ≤ -20℃ for 3 months.
Reconstitution	Centrifuge tubes before opening. Dissolve the lyophilized protein in distilled water. Do not mix by vortex. It is recommended to dissolve the product at a concentration of twice the specified specification.
Background	Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.

Specifications

Formulation	Lyophilized from sterile PBS, pH 7.4, 5% trehalose.
Purity	≥95% as determined by SDS-PAGE
Endotoxin	< 1EU/ug
Bio Activity	Immobilized Anti-Mouse IL-1B Antibody at 0.2 ug/mL (50 uL/well) can bind Mouse IL-1B with a linear range of 48.83 - 25,000 pg/mL.

Data

Greater than 95% as determined by reducing SDS-PAGE.

Bioactivity — Immobilized Anti-Mouse IL-1B Antibody at 0.2 ug/mL (50 uL/well) can bind Mouse IL-1B with a linear range of 48.83 - 25,000 pg/mL. (EC50 = 1.17 ng/mL)

分子信息

概述小鼠 IL2, IL-2 靶点信息

IL2 分子靶点信息概述

分子名：IL2, interleukin 2
基因家族：Interleukins
别名：IL-2; TCGF
全称：T cell growth factor

IL2 分子靶点综述

白细胞介素2(IL-2)是15kDa的糖蛋白，在人类中，由位于4号染色体q26–28区域的单基因编码。它是免疫系统中的一类信号分子，调控对具有免疫功能的白血球(白细胞，通常是淋巴细胞)的活性。IL-2是机体对微生物感染的天然应答，区别外来和自身抗原。IL-2通过与IL-2受体来发挥功能，其受体由3条链组成，分别为α链(CD25)、β链(CD122)和γ链(CD132)。监测血清中的IL-2含量为多种病理状态提供更详细的视角，包括癌症、传染病、移植排斥、多发性硬化症、类风湿性关节炎、系统性红斑狼疮和I型糖尿病等。

小鼠 Mouse Il2 分子靶点信息

小鼠 Mouse Il2 靶点分子功能（预测）

Enables cytokine activity and interleukin-2 receptor binding activity. Involved in negative regulation of T-helper 17 cell differentiation. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of macromolecule metabolic process; and regulation of lymphocyte activation. Located in extracellular space. Is expressed in liver; omental bursa; thymus; and thymus primordium. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including Takayasu's arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Orthologous to human IL2 (interleukin 2).