P1107

Recombinant Human LIF

¥780.00 – ¥16,000.00

说明书

分子靶点：LIF, CDF, DIA
种属：人 (Human)
表达宿主：Escherichia coli
纯度：≥95% as determined by SDS-PAGE
内毒素：<1EU/ug

在售SKU: P1107, 70-P1107-10, 70-P1107-1000, 70-P1107-25, 70-P1107-50

描述

文章目录[隐藏]

General Information
Specifications
Data
分子信息
LIF 分子靶点信息概述
LIF 分子靶点综述
- 人 Human LIF 分子靶点信息
- 人 Human LIF靶点分子功能（预测）

General Information

Source	Escherichia coli
Synonyms	Leukemia Inhibitory Factor, Differentiation-stimulating factor, D factor, Melanoma-derived LPL inhibitor (MLPLI), Interleukin 6 family cytokine
Accession	P15108
Molecular Mass	19.6 KDa
Description	Recombinant Human LIF is a 19.6 kDa protein containing 180 amino acids residues, including three disulfide bonds.
Shipping	The product is shipped at 4 ℃ . Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Aliquot the reconstituted solution to minimize freeze-thaw cycles. Lyophilized protein should be stored at -20℃ to -80℃, stable for one year after receipt. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Reconstitution	Centrifuge tubes before opening. Dissolve the lyophilized protein in distilled water. Do not mix by vortex. It is recommended to dissolve the product at a concentration of twice the specified specification.
Background	LIF is a pleiotrophic factor produced by multiple cell types, including T cells, myelomonocytic lineages, fibroblasts, liver, heart and melanoma. LIF promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. Other activities include the stimulation of acute phase protein synthesis by hepatocytes, stimulation of differentiation of cholinergic nerves, and suppression of dipogenesis by inhibiting the lipoprotein lipase in adipocytes.

Specifications

Formulation	Lyophilized from sterile PBS, pH 7.4, 5% trehalose.
Purity	≥95% as determined by SDS-PAGE
Endotoxin	<1EU/ug
Bio Activity	Recombinant Human LIF can be detected by ELISA with a linear range of 15.6-1,000.0 pg/mL.

Data

Greater than 95% as determined by reducing SDS-PAGE.

Bioactivity — Recombinant Human LIF can be detected by ELISA with a linear range of 15.6-1,000.0 pg/mL.

分子信息

概述人 LIF, CDF, DIA 靶点信息

LIF 分子靶点信息概述

分子名：LIF, LIF interleukin 6 family cytokine
基因家族：Receptor ligands; Interleukin 6 type cytokine family
别名：CDF; DIA; HILDA
全称：differentiation inhibitory activity; differentiation-inducing factor; hepatocyte-stimulating factor III; cholinergic differentiation factor; human interleukin in DA cells; leukemia inhibitory factor; LIF, interleukin 6 family cytokine

LIF 分子靶点综述

白血病抑制因子(LIF)是一种白细胞介素6家族细胞因子，通过抑制分化影响细胞生长。当LIF水平下降时，细胞就会分化。活化的T细胞、单核细胞、星形胶质细胞、成骨细胞、角质形成细胞、肥大细胞和成纤维细胞都可表达LIF。LIF因其能诱导髓系白血病细胞的终端分化，阻止白血病细胞的持续增长而得名。LIF的其它特性包括促进生长、促进不同类型的靶细胞分化、影响骨代谢、恶病质、神经发育、胚胎发育和炎症。LIF参与孕期子宫内膜蜕膜化和胚胎植入子宫内膜的过程。女性体内的LIF和其它细胞因子水平下降时，就容易怀孕，但是不明原因复发性流产的风险会增加。研究表明重组人LIF可能有助于改善女性不明原因不孕不育的着床率。另外，LIF通常用来添加到干细胞培养基中来减少自发分化。

人 Human LIF 分子靶点信息

分子名：LIF, LIF interleukin 6 family cytokine
别称：
- CDF
- cholinergic differentiation factor
- D factor
- DIA
- differentiation inhibitory activity
- differentiation stimulating factor
- differentiation-inducing factor
- differentiation-stimulating factor
- hepatocyte-stimulating factor III
- HILDA
- human interleukin in DA cells
- leukemia inhibitory factor
- LIF, interleukin 6 family cytokine
- melanoma-derived LPL inhibitor
- MLPLI
基因序列：NCBI_Gene: 3976
蛋白序列：UniProtKB: P15018

人 Human LIF靶点分子功能（预测）

Enables cytokine activity; growth factor activity; and leukemia inhibitory factor receptor binding activity. Involved in several processes, including leukemia inhibitory factor signaling pathway; positive regulation of protein modification process; and regulation of epithelial cell differentiation involved in kidney development. Acts upstream of or within several processes, including positive regulation of MAPK cascade; positive regulation of macrophage differentiation; and positive regulation of protein phosphorylation. Located in cytosol.