P1262

Recombinant Human KGF (FGF-7)

¥900.00 – ¥15,400.00

说明书

分子靶点：FGF7, KGF
种属：人 (Human)
表达宿主：Escherichia coli
纯度：≥90% as determined by SDS-PAGE
内毒素：<1EU/ug

在售SKU: P1262, 70-P1262-10, 70-P1262-100, 70-P1262-1000, 70-P1262-50, 70-P1262-500

描述

文章目录[隐藏]

General Information
Specifications
Data
分子信息
FGF7 分子靶点信息概述
FGF7 分子靶点综述
- 人 Human FGF7 分子靶点信息
- 人 Human FGF7靶点分子功能（预测）

General Information

Source	Escherichia coli
Synonyms	Keratinocyte Growth Factor, Fibroblast Growth Factor-7, HBGF-7
Accession	P21781
Molecular Mass	18.9 KDa
Description	Recombinant Human KGF (FGF-7) is an 18.9 kDa protein consisting of 163 amino acid residues.
Shipping	The product is shipped at 4 ℃ . Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Aliquot the reconstituted solution to minimize freeze-thaw cycles. Lyophilized protein should be stored at -20℃ to -80℃, stable for one year after receipt. Aliquots of reconstituted samples are stable at ≤ -20℃ for 3 months.
Reconstitution	Centrifuge tubes before opening. Dissolve the lyophilized protein in distilled water. Do not mix by vortex. It is recommended to dissolve the product at a concentration of twice the specified specification.
Background	KGF (FGF-7) is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth, and the regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. KGF (FGF-7) is a mitogen factor specific for epithelial cells and keratinocytes. KGF (FGF-7) signals through FGFR 2b. KGF (FGF-7) plays a role in kidney and lung development, as well as in angiogenesis and wound healing.

Specifications

Formulation	Lyophilized from sterile PBS, pH 7.4, 5% trehalose.
Purity	≥90% as determined by SDS-PAGE
Endotoxin	<1EU/ug
Bio Activity	Immobilized Anti-Human KGF Antibody at 0.2 ug/ml (50uL/well) can bind Human KGF with a linear range of 2.0-2,000.0 pg/ml.

Data

Greater than 90% as determined by reducing SDS-PAGE.

Bioactivity — Immobilized Anti-Human KGF Antibody at 0.2 ug/ml (50uL/well) can bind Human KGF with a linear range of 2.0-2,000.0 pg/ml.

分子信息

概述人 FGF7, KGF 靶点信息

FGF7 分子靶点信息概述

分子名：FGF7, fibroblast growth factor 7
基因家族：Receptor ligands; Fibroblast growth factor family
别名：KGF
全称：keratinocyte growth factor; fibroblast growth factor 7 (keratinocyte growth factor)

FGF7 分子靶点综述

角质细胞生长因子(KGF)，也被称为成纤维细胞生长因子7(FGF-7)，是伤口愈合上皮化阶段的生长因子。在这个阶段中，角质细胞覆盖伤口，形成上皮细胞。成纤维细胞、胚胎间充质细胞和平滑肌细胞可表达KGF。KGF是小信号分子，需结合成纤维细胞生长因子受体2b(FGFR2b)才能产生信号。研究显示，KGF是许多不同上皮细胞类型的旁分泌效应者。KGF不仅可诱导细胞增殖，还可促进上皮细胞分化。细胞因子如IL-1α和IL-1β、IL-6不仅激活局部结缔组织细胞，清除异物和重塑组织，同样可刺激成纤维细胞KGF的产生，促进再上皮化和伤口愈合。

人 Human FGF7 分子靶点信息

分子名：FGF7, fibroblast growth factor 7
别称：
- FGF-7
- HBGF-7
- heparin-binding growth factor 7
- keratinocyte growth factor
- KGF
基因序列：NCBI_Gene: 2252
蛋白序列：UniProtKB: P21781

人 Human FGF7靶点分子功能（预测）

Enables chemoattractant activity. Involved in several processes, including positive regulation of keratinocyte migration; positive regulation of keratinocyte proliferation; and protein localization to cell surface. Acts upstream of or within fibroblast growth factor receptor signaling pathway and positive regulation of epithelial cell proliferation involved in lung morphogenesis. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Biomarker of several diseases, including inflammatory bowel disease (multiple); leiomyoma; prostatic hypertrophy; reproductive organ cancer (multiple); and severe acute respiratory syndrome.