Rat Total MMP-9 Standard (大鼠总基质金属蛋白酶9 标准品)

MMP9 分子靶点信息概述

• 分子名：MMP9, matrix metallopeptidase 9
• 基因家族：M10 matrix metallopeptidases
• 曾用名：CLG4B
• 全称：matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

MMP9 分子靶点综述

基质金属蛋白酶9(MMP-9)，又名92kDaIV型胶原酶、92kDa明胶酶或者明胶酶B，是一类属于锌-金属蛋白酶家族的酶。MMP-9参与正常生理过程(如胚胎发育、繁殖、血管形成、骨骼发育、伤口愈细胞迁移、学习和记忆)和病理过程(如关节炎、脑出血和肿瘤转移)的细胞外基质降解。MMP-9和弹性蛋白酶似乎是中性粒细胞迁移通过基底膜的调节因子。MMP-9在血管和新生血管形成中起重要作用。它在人类呼吸道上皮愈合过程中被显著上调，并被发现与许多病理过程相关，如癌症、免疫和心血管疾病。在类风湿性关节炎、局灶性脑缺血案例中可发现MMP-9的水平是升高的。它的水平随着特发性房颤的发展而增加。

大鼠 Rat Mmp9 分子靶点信息

• 分子名：Mmp9, matrix metallopeptidase 9
• 别称：
  • 92 kDa gelatinase
  • 92 kDa type IV collagenase
  • 92-kDa type IV collagenase
  • gelatinase B
  • GELB
  • matrix metalloproteinase 9 (gelatinase B 92-kDa type IV collagenase)
  • matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase)
  • matrix metalloproteinase-9
  • MMP-9
• 基因序列：NCBI_Gene: 81687
• 蛋白序列：
  • UniprotKB: A0A0G2JUD9
  • UniprotKB: A0A8A1UC80
  • UniprotKB: A0A8A1UDE0
  • UniprotKB: D3ZYK8
  • UniprotKB: P50282

大鼠 Rat Mmp9 靶点分子功能（预测）

Enables fibronectin binding activity and metallopeptidase activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to cytokine stimulus; and cellular response to iron(III) ion. Located in extracellular space. Part of protein-containing complex. Used to study artery disease (multiple); brain ischemia (multiple); congestive heart failure; glomerulosclerosis; and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); chronic obstructive pulmonary disease (multiple); glucose metabolism disease (multiple); and kidney disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and chronic obstructive pulmonary disease (multiple). Orthologous to human MMP9 (matrix metallopeptidase 9).