Rat EGF Standard (大鼠表皮生长因子 (EGF) 标准品)

EGF 分子靶点信息概述

• 分子名：EGF, epidermal growth factor
• 全称：Pro-epidermal growth factor; epidermal growth factor (beta-urogastrone)

EGF 分子靶点综述

表皮生长因子(EGF)是一种通过与其受体EGFR结合，刺激细胞生长、增殖和分化的生长因子。EGF是小分子量多肽，最迟从小鼠下颌下腺纯化得到，随后在很多人的组织中均有发现，包括下颌下腺和腮腺。由饮食中的无机碘调控的唾液EGF在维持奥罗食管和胃组织健全方面具有重要的生理作用。唾液EGF的生理作用包括治愈口腔和胃溃疡、抑制胃酸分泌、刺激DNA合成以及保护粘膜免受腔内有害因素(如胃酸、胆汁酸、胃蛋白酶和胰蛋白酶)和物理、化学和细菌因素破坏。在某些通常与受体的突变和功能异常(如不依赖于EGF水平或与EGF结合的组成性受体信号传导)有关的癌症中，可观察到EGF受体活性增强。

大鼠 Rat Egf 分子靶点信息

• 分子名：Egf, epidermal growth factor
• 别称：
  • LOC103691699
  • pro-epidermal growth factor
  • uncharacterized LOC103691699
• 基因序列：NCBI_Gene: 25313
• 蛋白序列：
  • UniprotKB: A0A0G2K4M4
  • UniprotKB: A0A0G2K7A3
  • UniprotKB: A0A0G2KAF5
  • UniprotKB: J9SG97
  • UniprotKB: P07522

大鼠 Rat Egf 靶点分子功能（预测）

Enables epidermal growth factor receptor binding activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of ERK1 and ERK2 cascade; and positive regulation of fibroblast proliferation. Acts upstream of or within regulation of protein transport. Located in extracellular space. Used to study perinatal necrotizing enterocolitis. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); high grade glioma (multiple); lung non-small cell carcinoma (multiple); and primary hypomagnesemia (multiple). Orthologous to human EGF (epidermal growth factor).