Mouse ST2/IL-33R Standard (小鼠致癌抑制因子2 (ST2) 标准品)

IL1RL1 分子靶点信息概述

• 分子名：IL1RL1, interleukin 1 receptor like 1
• 基因家族：I-set domain containing; Interleukin receptors; TIR domain containing
• 别名：ST2; FIT-1; ST2L; ST2V; DER4; T1; IL33R
• 全称：homolog of mouse growth stimulation-expressed

IL1RL1 分子靶点综述

致癌抑制因子2(ST2)也称为IL-1R4，是IL-1受体家族糖蛋白成员，可促使Th2免疫应答。ST2表达于肥大细胞、活化的Th2细胞、巨噬细胞和心肌细胞表面。它与具有胞内和胞外活性的促炎性IL-1家族成员IL-33结合。除了其促进肥大细胞和Th2依赖的炎症作用，跨膜ST2的活化可增强炎症相关的反应，保护机体免受动脉粥样硬化和心肌细胞肥大的伤害。血清中可溶性ST2在炎症时的表达水平会升高，包括过敏性哮喘、败血症、创伤、登革热和肺部疾病。血清ST2的升高也受心力衰竭的多方面影响，包括主动脉瓣狭窄、充血性心肌病和心血管衰竭和死亡风险。

小鼠 Mouse Il1rl1 分子靶点信息

• 分子名：Il1rl1, interleukin 1 receptor-like 1
• 别称：
  • DER4
  • Fit-1
  • Ly84
  • lymphocyte antigen 84
  • signal transduction protein 2
  • signal transduction protein 2, related sequence 1
  • ST2
  • St2
  • St2-rs1
  • ST2L
  • T1
  • T1 gene
  • T1/ST2
• 基因序列：NCBI_Gene: 17082
• 蛋白序列：
  • UniprotKB: P14719
  • UniprotKB: G3UYU3
  • UniprotKB: Q3UM53
  • UniprotKB: Q5D095

小鼠 Mouse Il1rl1 靶点分子功能（预测）

Enables interleukin-33 binding activity and interleukin-33 receptor activity. Involved in several processes, including negative regulation of T-helper 1 type immune response; positive regulation of macrophage activation; and regulation of cytokine production. Acts upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling. Located in external side of plasma membrane and extracellular matrix. Is expressed in several structures, including immune system; musculoskeletal system; salivary gland; skin; and visual system. Human ortholog(s) of this gene implicated in asthma and coronary artery disease. Orthologous to human IL1RL1 (interleukin 1 receptor like 1).