Mouse PDGF-BB Standard (小鼠血小板衍生因子BB (PDGF-BB) 标准品)

PDGFB 分子靶点信息概述

• 分子名：PDGFB, platelet derived growth factor subunit B
• 别名：SSV
• 曾用名：SIS
• 全称：oncogene SIS; becaplermin; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); platelet-derived growth factor beta polypeptide

PDGFB 分子靶点综述

血小板衍生因子(PDGF)是众多调节细胞生长和分裂的因子之一。从化学结构上来说，PDGF是一种由两条A链(-AA)或两条B链(-BB)或AB链组合(-AB)形成的二聚体糖蛋白。特别是，它在血管生成、已存在的血管组织生长中起着重要作用。不受控制的血管生成是肿瘤的一个特征。肝细胞和不吸收的破骨细胞表达PDGF-BB，产生成骨细胞和骨头，血小板、巨噬细胞和肥大细胞也能产生PDGF-BB。在损伤部位，PDGF-BB促进中性粒细胞和巨噬细胞浸润，发挥清创作用，促进成纤维细胞分泌新的细胞外基质，促进IGF-1介导再上皮化。

小鼠 Mouse Pdgfb 分子靶点信息

• 分子名：Pdgfb, platelet derived growth factor, B polypeptide
• 别称：
  • PDGF-B
  • simian sarcoma oncogene
  • Sis
• 基因序列：NCBI_Gene: 18591
• 蛋白序列：
  • UniprotKB: P31240
  • UniprotKB: A0A0R4IZW4
  • UniprotKB: A0A2R8VHJ1
  • UniprotKB: A0A2R8W6F2
  • UniprotKB: Q549C6
  • UniprotKB: Q8R3X9

小鼠 Mouse Pdgfb 靶点分子功能（预测）

Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and receptor ligand activity. Involved in several processes, including metanephric glomerular mesangium development; paracrine signaling; and positive regulation of glomerular filtration. Acts upstream of or within several processes, including animal organ development; nervous system development; and regulation of cell migration. Predicted to be located in several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; extraembryonic component; female reproductive system; and nervous system. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue cancer (multiple); familial meningioma; and prostatic hypertrophy. Orthologous to human PDGFB (platelet derived growth factor subunit B).