Mouse osteopontin/OPN Standard (小鼠骨桥蛋白 标准品)

SPP1 分子靶点信息概述

• 分子名：SPP1, secreted phosphoprotein 1
• 基因家族：Receptor ligands; SIBLING family
• 别名：BSPI; ETA-1
• 曾用名：BNSP; OPN
• 全称：early T-lymphocyte activation 1; osteopontin; bone sialoprotein I

SPP1 分子靶点综述

骨桥蛋白(OPN)，又名BSP-1、ETA-1、SPP-1或Ric，在人类中由SPP1基因编码，主要在骨骼中表达。OPN基因的调节机制还未完全阐明，不同细胞类型的调节机理是不同的。OPN在生物矿化、骨重塑、免疫功能、趋化、细胞活化和凋亡上有作用，同样与心肌细胞凋亡和心肌功能紊乱的增加有关。OPN与许多生理和病理过程包括伤口愈合、骨转换、肿瘤发生、炎症、缺血和免疫应答有关。调控血浆(或局部)的OPN水平对治疗自身免疫性疾病、癌症转移、骨和牙齿的矿化、骨质疏松症和一些应激形式有帮助。

小鼠 Mouse Spp1 分子靶点信息

• 分子名：Spp1, secreted phosphoprotein 1
• 别称：
  • 2ar
  • 44kDa bone phosphoprotein
  • AA960535
  • activation protein lymphocyte 1
  • AI790405
  • Apl-1
  • BNSP
  • bone sialoprotein 1
  • early T lymphocyte activation
  • Eta
  • ETA-1
  • expressed sequence AA960535
  • expressed sequence AI790405
  • minopontin
  • OP
  • Opn
  • Opnl
  • osteopontin
  • osteopontin-like protein
  • Ric
  • rickettsia tsutsugamushi resistance
  • Spp-1
• 基因序列：NCBI_Gene: 20750
• 蛋白序列：
  • UniprotKB: P10923
  • UniprotKB: D3Z116
  • UniprotKB: D3Z4N2
  • UniprotKB: D3Z513
  • UniprotKB: F8WIP8
  • UniprotKB: Q3TLP1
  • UniprotKB: Q3TND2
  • UniprotKB: Q3UBR1
  • UniprotKB: Q3UZY3
  • UniprotKB: Q547B5
  • UniprotKB: Q66JX3

小鼠 Mouse Spp1 靶点分子功能（预测）

Enables extracellular matrix binding activity. Acts upstream of or within several processes, including cellular ion homeostasis; cellular response to leukemia inhibitory factor; and neutrophil chemotaxis. Located in apical part of cell and cytoplasm. Is expressed in several structures, including alimentary system; brain; metanephros; reproductive system; and skeleton. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1).