Mouse IL-10 Standard (小鼠白细胞介素10 标准品)

IL10 分子靶点信息概述

• 分子名：IL10, interleukin 10
• 基因家族：Interleukins
• 别名：CSIF; TGIF; IL10A; IL-10
• 全称：cytokine synthesis inhibitory factor; T-cell growth inhibitory factor

IL10 分子靶点综述

白细胞介素10(IL-10)是由2个长178个氨基酸的亚基构成的同源二聚体。在人类中，它由位于1号染色体的IL-10基因编码，由5个外显子组成。IL-10主要由单核细胞分泌，淋巴细胞、II型辅助性T细胞(Th2)、肥大细胞、CD4+CD25+Foxp3+调节性T细胞和部分活化的T细胞和B细胞分泌较少。它对免疫调控和炎症具有多种效应。它下调巨噬细胞的Th1细胞因子、II类MHC抗原和共刺激分子。它还能增强B细胞存活、增殖和抗体分泌。IL-10能阻断NF-κB活性，并参与JAK-STAT信号通路调控。IL-10的免疫抑制特性提示其可能应用于临床，抑制器官移植后的排斥。IL-10还具有强烈的消炎特性。

小鼠 Mouse Il10 分子靶点信息

• 分子名：Il10, interleukin 10
• 别称：
  • cytokine synthesis inhibitory factor
  • IL-10
  • Il-10
• 基因序列：NCBI_Gene: 16153
• 蛋白序列：
  • UniprotKB: P18893
  • UniprotKB: A0A7R8GUQ3
  • UniprotKB: Q3U879

小鼠 Mouse Il10 靶点分子功能（预测）

Enables cytokine activity. Involved in several processes, including negative regulation of cell death; negative regulation of heterotypic cell-cell adhesion; and negative regulation of vascular associated smooth muscle cell proliferation. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; negative regulation of cytokine production; and response to bacterium. Located in extracellular space. Is expressed in colon; liver; thymus; and thymus primordium. Used to study inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human IL10 (interleukin 10).