Mouse EGF Standard (小鼠EGF 标准品)

EGF 分子靶点信息概述

• 分子名：EGF, epidermal growth factor
• 全称：Pro-epidermal growth factor; epidermal growth factor (beta-urogastrone)

EGF 分子靶点综述

表皮生长因子(EGF)是一种通过与其受体EGFR结合，刺激细胞生长、增殖和分化的生长因子。EGF是小分子量多肽，最迟从小鼠下颌下腺纯化得到，随后在很多人的组织中均有发现，包括下颌下腺和腮腺。由饮食中的无机碘调控的唾液EGF在维持奥罗食管和胃组织健全方面具有重要的生理作用。唾液EGF的生理作用包括治愈口腔和胃溃疡、抑制胃酸分泌、刺激DNA合成以及保护粘膜免受腔内有害因素(如胃酸、胆汁酸、胃蛋白酶和胰蛋白酶)和物理、化学和细菌因素破坏。在某些通常与受体的突变和功能异常(如不依赖于EGF水平或与EGF结合的组成性受体信号传导)有关的癌症中，可观察到EGF受体活性增强。

小鼠 Mouse Egf 分子靶点信息

• 分子名：Egf, epidermal growth factor
• 别称：
  • AI790464
  • expressed sequence AI790464
• 基因序列：NCBI_Gene: 13645
• 蛋白序列：
  • UniprotKB: P01132
  • UniprotKB: A0A0G2JDT8
  • UniprotKB: A0A0G2JF92
  • UniprotKB: A0A0G2JFB8
  • UniprotKB: Q3UWD7
  • UniprotKB: Q8VD07

小鼠 Mouse Egf 靶点分子功能（预测）

Enables epidermal growth factor receptor binding activity. Involved in several processes, including negative regulation of cholesterol efflux; positive regulation of ubiquitin-dependent protein catabolic process; and regulation of receptor signaling pathway via JAK-STAT. Acts upstream of or within several processes, including mammary gland alveolus development; positive regulation of cerebellar granule cell precursor proliferation; and positive regulation of protein tyrosine kinase activity. Located in extracellular space and plasma membrane. Is expressed in several structures, including 1st branchial arch; alimentary system; brain; genitourinary system; and liver and biliary system. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); high grade glioma (multiple); lung non-small cell carcinoma (multiple); and primary hypomagnesemia (multiple). Orthologous to human EGF (epidermal growth factor).