Mouse CCL5/RANTES Standard (小鼠 CCL5/RANTES 标准品)

CCL5 分子靶点信息概述

• 分子名：CCL5, C-C motif chemokine ligand 5
• 基因家族：Chemokine ligands
• 别名：RANTES; SISd; TCP228; MGC17164
• 曾用名：D17S136E; SCYA5
• 全称：T-cell specific protein p288; T-cell specific RANTES protein; SIS-delta; regulated upon activation, normally T-expressed, and presumably secreted; beta-chemokine RANTES; small inducible cytokine subfamily A (Cys-Cys), member 5; small inducible cytokine A5 (RANTES); chemokine (C-C motif) ligand 5

CCL5 分子靶点综述

趋化因子配体5(CCL5)，又名RANTES，是一种趋化细胞因子。它可趋化T细胞、嗜酸性粒细胞和嗜碱性粒细胞，在招募白细胞到炎症位点发挥着积极的作用。在T细胞释放的细胞因子如IL-2和IFN-γ的帮助下，CCL5可诱导某些自然杀伤细胞(NK)增殖和活化形成CC趋化因子活化的杀伤(CHAK)细胞。CCL5也是一种由CD8+T细胞释放的HIV抑制因子。最近，研究者正在开发完善乳酸菌体内产生CCL5的方案，以期其成为抑制HIV进入的局部杀菌剂。

小鼠 Mouse Ccl5 分子靶点信息

• 分子名：Ccl5, chemokine (C-C motif) ligand 5
• 别称：
  • MuRantes
  • RANTES
  • Scya5
  • SISd
  • small inducible cytokine A5
  • TCP228
• 基因序列：NCBI_Gene: 20304
• 蛋白序列：
  • UniprotKB: P30882
  • UniprotKB: Q5XZF2

小鼠 Mouse Ccl5 靶点分子功能（预测）

Enables CCR1 chemokine receptor binding activity. Involved in negative regulation of macrophage apoptotic process and positive regulation of monocyte chemotaxis. Acts upstream of or within inflammatory response; positive regulation of epithelial cell proliferation; and response to tumor necrosis factor. Located in cytoplasm and extracellular space. Is expressed in several structures, including central nervous system; gonad; hemolymphoid system; late tubule; and retina. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; liver disease (multiple); pulmonary tuberculosis; and severe acute respiratory syndrome. Orthologous to human CCL5 (C-C motif chemokine ligand 5).