Mouse BAFF/BLyS/TNFSF13B Standard (小鼠BAFF/BLyS/TNFSF13B 标准品)

TNFSF13B 分子靶点信息概述

• 分子名：TNFSF13B, TNF superfamily member 13b
• 基因家族：CD molecules; Tumor necrosis factor superfamily
• 别名：BAFF; THANK; BLYS; TALL-1; TALL1; CD257
• 曾用名：TNFSF20
• 全称：B-cell-activating factor; TNF and ApoL-related leukocyte expressed ligand 1; TNF homolog that activates apoptosis; B-lymphocyte stimulator; tumor necrosis factor (ligand) superfamily, member 13b

TNFSF13B 分子靶点综述

B细胞活化因子(BAFF)也称为B淋巴细胞刺激因子(BLys)或肿瘤坏死因子配体超家族成员13B(TNFSF13B)，表达于B细胞系的细胞，并作为有效的B细胞激活剂，对B细胞的增殖和分化具有重要作用。BAFF在作为免疫刺激剂，是维持正常免疫所必需的。BAFF表达不足会无法活化B细胞产生足够的免疫球蛋白，并导致免疫缺陷。BAFF表达过度会引起抗体分泌量过高，导致系统性红斑狼疮、类风湿性关节炎和其它自身免疫疾病。

小鼠 Mouse Tnfsf13b 分子靶点信息

• 分子名：Tnfsf13b, tumor necrosis factor (ligand) superfamily, member 13b
• 别称：
  • BAFF
  • BLyS
  • D8Ertd387e
  • DNA segment, Chr 8, ERATO Doi 387, expressed
  • TALL-1
  • zTNF4
• 基因序列：NCBI_Gene: 24099
• 蛋白序列：
  • UniprotKB: Q9WU72
  • UniprotKB: A0A0U5J6R6
  • UniprotKB: Q3KP92
  • UniprotKB: Q3U2H2
  • UniprotKB: Q8BVA3
  • UniprotKB: Q8BWP2
  • UniprotKB: Q8BZM8

小鼠 Mouse Tnfsf13b 靶点分子功能（预测）

Predicted to enable receptor ligand activity. Involved in B cell differentiation and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within B cell homeostasis; positive regulation of germinal center formation; and positive regulation of lymphocyte activation. Predicted to be located in several cellular components, including focal adhesion; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in extracellular space. Is expressed in genitourinary system. Used to study IgA glomerulonephritis and Sjogren's syndrome. Orthologous to human TNFSF13B (TNF superfamily member 13b).