Human VEGF R1/Flt-1 Standard (人血管内皮生长因子受体1 (VEGF R1) 标准品)

FLT1 分子靶点信息概述

• 分子名：FLT1, fms related receptor tyrosine kinase 1
• 基因家族：Receptor tyrosine kinases; I-set domain containing
• 别名：VEGFR1
• 曾用名：FLT
• 全称：vascular endothelial growth factor receptor 1; vascular permeability factor receptor; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); fms-related tyrosine kinase 1; fms related tyrosine kinase 1

FLT1 分子靶点综述

血管内皮生长因子受体1(VEGF R1)也称为Flt-1，是血管生成因子VEGF (VEGF-A)、胎盘生长因子(PIGF)和VEGF-B的特异性酪氨酸激酶 (RTK) 受体。根据剪切形式，存在膜型 (mbVEGFR)和可溶性(sVEGFR) 两种形式。实验和临床上注射sVEGF R1成功地阻止了血管新生和肿瘤生长。在不同的病理条件下，血清/血浆中的sVEGF R1含量有所不同，可能具有诊断价值。在实验和病理条件下，sVEGF R1和VEGF水平相关。在孕妇和原发性高血压患者的血浆中存在高水平的sVEGF R1。心血管疾病患者和吸烟者的血浆中，sVEGF R1水平显著降低。

人 Human FLT1 分子靶点信息

• 分子名：FLT1, fms related receptor tyrosine kinase 1
• 别称：
  • FLT
  • FLT-1
  • fms related tyrosine kinase 1
  • fms-like tyrosine kinase 1
  • fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  • tyrosine-protein kinase FRT
  • tyrosine-protein kinase receptor FLT
  • vascular endothelial growth factor receptor 1
  • vascular permeability factor receptor
  • VEGFR-1
  • VEGFR1
• 基因序列：NCBI_Gene: 2321
• 蛋白序列：UniProtKB: P17948

人 Human FLT1靶点分子功能（预测）

Enables growth factor binding activity; placental growth factor-activated receptor activity; and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including monocyte chemotaxis; positive regulation of kinase activity; and protein phosphorylation. Located in actin cytoskeleton and plasma membrane. Is integral component of plasma membrane. Part of receptor complex. Implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Biomarker of several diseases, including Kawasaki disease; Leydig cell tumor; cerebrovascular disease (multiple); kidney cancer (multiple); and retinal disease (multiple).