Human P4HB Standard (人脯氨酸4-羟化酶β亚基 (P4HB) 标准品)

P4HB 分子靶点信息概述

• 分子名：P4HB, prolyl 4-hydroxylase subunit beta
• 基因家族：Protein disulfide isomerases
• 别名：PDIA1; PROHB; DSI; GIT; PDI; PO4HB; P4Hbeta
• 曾用名：PO4DB; ERBA2L
• 全称：protein disulfide isomerase-associated 1; protein disulfide isomerase family A, member 1; collagen prolyl 4-hydroxylase beta; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase; thyroid hormone binding protein p55); procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase-associated 1); procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide; prolyl 4-hydroxylase, beta polypeptide

P4HB 分子靶点综述

蛋白质二硫键异构酶，又称脯氨酸4-羟化酶β亚基(P4HB)、细胞甲状腺激素结合蛋白(p55)和谷胱甘肽-胰岛素转氢酶，是一种外周膜蛋白，属于蛋白二硫键异构酶家族。它包含两个硫氧还蛋白结构域，催化二硫键的形成、断裂和重排。P4HB定位于淋巴细胞表面CD4富集区附近。在黑素小体组分中，P4HB可降低并激活HIV-1 gp120表面蛋白的融合特性，从而使HIV-1进入细胞。P4HB作为一种伴侣，抑制错误折叠蛋白的聚集。P4HB可能与其它分子伴侣参与了激素生物合成中TG前体的结构修饰。

人 Human P4HB 分子靶点信息

• 分子名：P4HB, prolyl 4-hydroxylase subunit beta
• 别称：
  • cellular thyroid hormone-binding protein
  • CLCRP1
  • collagen prolyl 4-hydroxylase beta
  • DSI
  • ERBA2L
  • GIT
  • glutathione-insulin transhydrogenase
  • P4Hbeta
  • p55
  • PDI
  • PDIA1
  • PHDB
  • PO4DB
  • PO4HB
  • procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide
  • PROHB
  • prolyl 4-hydroxylase, beta polypeptide
  • protein disulfide isomerase family A, member 1
  • protein disulfide isomerase-associated 1
  • protein disulfide isomerase/oxidoreductase
  • protein disulfide-isomerase
  • protocollagen hydroxylase
  • testicular secretory protein Li 32
  • thyroid hormone-binding protein p55
  • v-erb-a avian erythroblastic leukemia viral oncogene homolog 2-like
• 基因序列：NCBI_Gene: 5034
• 蛋白序列：UniProtKB: P07237

人 Human P4HB靶点分子功能（预测）

Enables several functions, including oxidoreductase activity, acting on a sulfur group of donors; protein disulfide isomerase activity; and protein heterodimerization activity. Contributes to procollagen-proline 4-dioxygenase activity. Involved in several processes, including positive regulation of substrate adhesion-dependent cell spreading; positive regulation of viral entry into host cell; and protein folding in endoplasmic reticulum. Acts upstream of or within peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Located in several cellular components, including endoplasmic reticulum-Golgi intermediate compartment; external side of plasma membrane; and lamellipodium. Part of procollagen-proline 4-dioxygenase complex. Implicated in Cole-Carpenter syndrome.