Human Her3/ErbB3 Standard (人表皮生长因子受体3 标准品)

ERBB3 分子靶点信息概述

• 分子名：ERBB3, erb-b2 receptor tyrosine kinase 3
• 基因家族：Erb-b2 receptor tyrosine kinases
• 别名：LCCS2; HER3; HER-3
• 曾用名：LCCS2
• 全称：lethal congenital contracture syndrome 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; human epidermal growth factor receptor 3

ERBB3 分子靶点综述

人表皮生长因子受体3 (human epidermal growth factor receptor 3, Her3)，也称ErbB3，是一种I型跨膜糖蛋白，是酪氨酸激酶受体ErbB家族的成员。ErbB3结合神经调节蛋白NRG1和NRG2，但缺少一个有效的激酶结构域；与另一个ErbB受体的异二聚作用是信号转导所必需的。ErbB3在雪旺细胞、神经嵴细胞、心脏瓣膜和交感神经系统的发育中起重要作用。这种基因的扩增和/或其蛋白的过度表达在许多癌症中都有报道，包括前列腺癌、膀胱癌和乳腺癌。ErbB3在多种肿瘤中高表达，激活时可引起肿瘤增殖及药物抵抗性。E3泛素连接酶、单克隆抗体以及microRNA是当前调节ErbB3表达及功能的主要分子标志物。

人 Human ERBB3 分子靶点信息

• 分子名：ERBB3, erb-b2 receptor tyrosine kinase 3
• 别称：
  • avian erythroblastosis oncogene b 3
  • c-erbB-3
  • c-erbB3
  • ErbB-3
  • erbB3-S
  • FERLK
  • HER3
  • human epidermal growth factor receptor 3
  • LCCS2
  • MDA-BF-1
  • MGC88033
  • p180-ErbB3
  • p45-sErbB3
  • p85-sErbB3
  • proto-oncogene-like protein c-ErbB-3
  • receptor tyrosine-protein kinase erbB-3
  • tyrosine kinase-type cell surface receptor HER3
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
  • VSCN1
• 基因序列：NCBI_Gene: 2065
• 蛋白序列：UniProtKB: P21860

人 Human ERBB3靶点分子功能（预测）

Enables several functions, including ErbB-3 class receptor binding activity; neuregulin binding activity; and protein heterodimerization activity. Involved in several processes, including extrinsic apoptotic signaling pathway in absence of ligand; phosphatidylinositol 3-kinase signaling; and positive regulation of protein tyrosine kinase activity. Located in basolateral plasma membrane and extracellular space. Part of ERBB3:ERBB2 complex. Implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Biomarker of carcinoma (multiple); ductal carcinoma in situ; prostate cancer; and urinary bladder cancer.