Human CTLA-4/CD152 Standard (人细胞毒性T淋巴细胞相关蛋白4 标准品)

CTLA4 分子靶点信息概述

• 分子名：CTLA4, cytotoxic T-lymphocyte associated protein 4
• 基因家族：CD molecules; V-set domain containing
• 别名：CD152; CD; GSE; CTLA-4
• 曾用名：CELIAC3; IDDM12
• 全称：celiac disease 3; insulin-dependent diabetes mellitus 12

CTLA4 分子靶点综述

细胞毒性 T 淋巴细胞相关蛋白 4 (CTLA-4)，又名 CD152，是免疫球蛋白超家族中的成员，在辅助型 T 细胞表面表达。 CTLA-4 类似于 T 细胞的共刺激蛋白 CD28，它们都结合 CD80 和 CD86。CTLA-4 传递抑制信号给 T 细胞，而 CD28 则传 递刺激信号。CTLA-4 可作为免疫检查点发挥功能、下调免疫系统、当结合抗原递呈细胞表面的 CD80 或 CD86 时作为“关 闭”开关。细胞内的 CTLA-4 同样存在于调节性 T 细胞中，对它们的功能发挥是重要的。该基因突变与胰岛素依赖型糖尿病、甲状腺机能亢进、桥本甲状腺炎、乳糜泻、系统性红斑狼疮、甲状腺相关眼病、 原发性胆汁性肝硬化和其它自身免疫性疾病有关。CTLA-4 基因的多态性与自身免疫性疾病如自身免疫性甲状腺疾病和多 发性硬化症有关，但这种关联性通常较弱。在系统性红斑狼疮中，人们发现可溶性 CTLA-4 的剪接变异体异常产生，且存 在于患有该病的患者血清中。

人 Human CTLA4 分子靶点信息

• 分子名：CTLA4, cytotoxic T-lymphocyte associated protein 4
• 别称：
  • ALPS5
  • CD
  • CD152
  • cd152 antigen
  • CD152 isoform
  • celiac disease 3
  • CELIAC3
  • CTLA-4
  • cytotoxic T lymphocyte associated antigen 4 short spliced form
  • cytotoxic T-lymphocyte antigen 4
  • cytotoxic T-lymphocyte protein 4
  • cytotoxic T-lymphocyte-associated antigen 4
  • cytotoxic T-lymphocyte-associated protein 4
  • cytotoxic T-lymphocyte-associated serine esterase-4
  • GRD4
  • GSE
  • ICOS
  • IDDM12
  • insulin-dependent diabetes mellitus 12
  • ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
• 基因序列：NCBI_Gene: 1493
• 蛋白序列：UniProtKB: P16410

人 Human CTLA4靶点分子功能（预测）

Involved in several processes, including B cell receptor signaling pathway; negative regulation of lymphocyte activation; and positive regulation of apoptotic process. Located in several cellular components, including clathrin-coated endocytic vesicle; external side of plasma membrane; and perinuclear region of cytoplasm. Is integral component of plasma membrane. Part of protein complex involved in cell adhesion. Implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); hepatitis B; kidney disease (multiple); and primary immunodeficiency disease (multiple). Biomarker of several diseases, including Sjogren's syndrome; anogenital venereal wart; hepatitis A; lung disease (multiple); and tropical spastic paraparesis.