Human Bcl-2 Standard (人B细胞淋巴瘤2 标准品)

BCL2 分子靶点信息概述

• 分子名：BCL2, BCL2 apoptosis regulator
• 基因家族：Protein phosphatase 1 regulatory subunits; BCL2 family
• 别名：Bcl-2; PPP1R50
• 全称：protein phosphatase 1, regulatory subunit 50; B-cell CLL/lymphoma 2; BCL2, apoptosis regulator

BCL2 分子靶点综述

B细胞淋巴瘤2 (Bcl-2)，是Bcl-2家族调节蛋白中的创始成员，可通过诱导凋亡(促凋亡)或者抑制凋亡(抗凋亡)来调节细胞凋亡。Bcl-2已明确是一种重要的抗凋亡蛋白，因此被归类为是一种致癌基因。Bcl-2调节线粒体动力学，并参与线粒体融合与分裂的调控。另外，在胰岛β细胞中，Bcl-2和Bcl-XL参与控制代谢活性和胰岛素分泌。 Bcl-2基因损伤会引发许多癌症，包括黑色素瘤、乳腺癌、前列腺癌、慢性淋巴细胞白血病和肺癌，还可能与精神分裂症和自身免疫性疾病有关。Bcl-2也是癌症治疗抵抗的一个原因。

人 Human BCL2 分子靶点信息

• 分子名：BCL2, BCL2 apoptosis regulator
• 别称：
  • apoptosis regulator Bcl-2
  • B-cell CLL/lymphoma 2
  • b-cell leukemia/lymphoma 2
  • Bcl-2
  • Bcl-2a
  • Bcl-2?
  • BCL2, apoptosis regulator
  • PPP1R50
  • protein phosphatase 1, regulatory subunit 50
• 基因序列：NCBI_Gene: 596
• 蛋白序列：UniProtKB: P10415

人 Human BCL2靶点分子功能（预测）

Enables several functions, including BH3 domain binding activity; enzyme binding activity; and protein heterodimerization activity. Involved in several processes, including B cell receptor signaling pathway; negative regulation of apoptotic process; and positive regulation of B cell proliferation. Acts upstream of or within several processes, including B cell proliferation; apoptotic signaling pathway; and negative regulation of apoptotic process. Located in endoplasmic reticulum; mitochondrial outer membrane; and nucleus. Part of pore complex. Implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; prostate cancer; and urinary bladder cancer. Biomarker of several diseases, including cervix uteri carcinoma in situ; ductal carcinoma in situ; gastrointestinal system cancer (multiple); hematologic cancer (multiple); and urinary system cancer (multiple).