EK1102S

Human BAFF/BLys/TNFSF13B Standard (人BAFF/BLys/TNFSF13B 标准品)

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¥280.00

  • 分子靶点:TNFSF13B, BAFF, CD257
  • 种属:人 (Human)
  • 试剂盒:EK1102
  • 保存:短期4℃保存,长期-20℃保存
  • 运输条件:4℃蓝冰运输

在售SKU:70-EK1102S, B, 细胞, 活化, 因子, B, 淋巴细胞, 刺激因子, 肿瘤, 坏死, 因子, 配体, 超家族, 成员, 13B


描述

本产品只包含标准品试剂,如需购买试剂盒请点击下图

商品名

Human BAFF/BLys/TNFSF13B Standard (人BAFF/BLys/TNFSF13B 标准品)

组分

人BAFF/BLys/TNFSF13B 标准品

检测方法

双抗夹心法

样本类型

血清,血浆,细胞培养上清及其他生物学样本

板式

保存

短期4℃,长期-20℃保存

运输条件

4℃蓝冰运输

检测原理:本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人BAFF抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品和待测样本,经过孵育,样本中存在的BAFF与固相抗体结合。洗涤去除未结合的物质后,加入生物素化的检测抗体孵育。洗涤去除未结合的生物素化的抗体,加入辣根过氧化物酶标记的链霉亲和素 (Streptavidin-HRP)。洗涤后,加入显色底物TMB,避光显色。颜色反应的深浅与样本中BAFF的浓度成正比。加入终止液终止反应,在450 nm波长(参考波长570 - 630 nm)测定吸光度值。

Human BAFF/BLys/TNFSF13B ELISA Kit (人BAFF/BLys/TNFSF13B ELISA试剂盒) - 标准曲线
标准曲线

分子信息

概述人 TNFSF13B, BAFF, CD257 靶点信息

TNFSF13B 分子靶点信息概述

  • 分子名:TNFSF13B, TNF superfamily member 13b
  • 基因家族:CD molecules; Tumor necrosis factor superfamily
  • 别名:BAFF; THANK; BLYS; TALL-1; TALL1; CD257
  • 曾用名:TNFSF20
  • 全称:B-cell-activating factor; TNF and ApoL-related leukocyte expressed ligand 1; TNF homolog that activates apoptosis; B-lymphocyte stimulator; tumor necrosis factor (ligand) superfamily, member 13b

TNFSF13B 分子靶点综述

B细胞活化因子(BAFF)也称为B淋巴细胞刺激因子(BLys)或肿瘤坏死因子配体超家族成员13B(TNFSF13B),表达于B细胞系的细胞,并作为有效的B细胞激活剂,对B细胞的增殖和分化具有重要作用。BAFF在作为免疫刺激剂,是维持正常免疫所必需的。BAFF表达不足会无法活化B细胞产生足够的免疫球蛋白,并导致免疫缺陷。BAFF表达过度会引起抗体分泌量过高,导致系统性红斑狼疮、类风湿性关节炎和其它自身免疫疾病。

人 Human TNFSF13B 分子靶点信息

  • 分子名:TNFSF13B, TNF superfamily member 13b
  • 别称:
    • ApoL related ligand TALL-1
    • b lymphocyte stimulator
    • B-cell activating factor
    • B-cell-activating factor
    • B-lymphocyte stimulator
    • BAFF
    • BLYS
    • CD257
    • delta BAFF
    • Delta4 BAFF
    • dendritic cell-derived TNF-like molecule
    • DTL
    • TALL-1
    • TALL1
    • THANK
    • TNF and ApoL-related leukocyte expressed ligand 1
    • TNF homolog that activates apoptosis
    • TNF- and APOL-related leukocyte expressed ligand 1
    • TNFSF20
    • TNLG7A
    • tumor necrosis factor (ligand) superfamily member 13b
    • tumor necrosis factor (ligand) superfamily, member 13b
    • tumor necrosis factor (ligand) superfamily, member 20
    • tumor necrosis factor ligand 7A
    • tumor necrosis factor ligand superfamily member 13B
    • tumor necrosis factor superfamily member 13b
    • tumor necrosis factor superfamily, member 13b
    • tumor necrosis factor-like protein ZTNF4
    • ZTNF4
  • 基因序列:NCBI_Gene: 10673
  • 蛋白序列:UniProtKB: Q9Y275

人 Human TNFSF13B靶点分子功能(预测)

Predicted to enable receptor ligand activity. Involved in positive regulation of B cell proliferation. Located in several cellular components, including focal adhesion; perinuclear region of cytoplasm; and plasma membrane.

操作步骤


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引用文献


  1. Circulating C-X-C Motif Ligand 13 as a Biomarker for Early Predicting Efficacy of Subcutaneous Immunotherapy in Children With Chronic Allergic Rhinitis 

  2. Immune recovery after in vivo T-cell depletion myeloablative conditioning hematopoietic stem cell transplantation in severe beta-thalassemia children 

  3. Circulating BAFF as novel biomarker in distinguishing chronic rhinosinusitis with nasal polyps endotypes and predicting postoperative recurrence 

  4. Characterization of CD19+CD24hiCD38hi B cells in Chinese adult patients with atopic dermatitis 

  5. Harnessing the cross-talk between tumor cells and tumor-associated macrophages with a nano-drug for modulation of glioblastoma immune microenvironment 

  6. Huoxue Jiedu Recipe represses mitochondrial fission to alleviate submandibular gland inflammation in Sj?gren's syndrome 

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