Anti-Mouse CD3ε, Functional Grade (Clone:145-2C11)功能抗体 (新品)

CD3E 分子靶点信息概述

• 分子名：CD3E, CD3e molecule
• 基因家族：CD molecules
• 全称：CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex)

CD3E 分子靶点综述

CD3也称为T3，是免疫球蛋白超家族的一员，在抗原识别、信号传导和T细胞活化中具有重要作用。CD3ε的分子量为20 kD，是CD3分子的亚基，后者由2个CD3ε、1个CD3γ、1个CD3δ和1个CD3ζ (CD247)构成，并与α/β或γ/δT细胞受体(TCR)形成异源二聚体。CD3表达于所有成熟T细胞、NKT细胞和部分胸腺细胞。

小鼠 Mouse Cd3e 分子靶点信息

• 分子名：Cd3e, CD3 antigen, epsilon polypeptide
• 别称：
  • AI504783
  • CD3
  • CD3epsilon
  • expressed sequence AI504783
  • T3-epsilon chain
  • T3e
• 基因序列：NCBI_Gene: 12501
• 蛋白序列：
  • UniprotKB: P22646
  • UniprotKB: A6H6M1
  • UniprotKB: B0LAX5

小鼠 Mouse Cd3e 靶点分子功能（预测）

Predicted to enable several functions, including SH3 domain binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in nervous system development and positive regulation of cell adhesion. Acts upstream of or within several processes, including positive regulation of T cell activation; positive regulation of cytokine production; and regulation of signal transduction. Located in several cellular components, including dendritic spine; external side of plasma membrane; and immunological synapse. Part of alpha-beta T cell receptor complex. Is expressed in colon and hemolymphoid system. Human ortholog(s) of this gene implicated in immunodeficiency 18. Orthologous to human CD3E (CD3e molecule).