Novus NFKB信号通路产品

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http://www.liankebio.com/article-information_Newsletter-1173.html

作者：Novus官网 发布日期：2014-05-15 12:00

核因子-KB（Nuclear factor-kappa B, NF-KB）蛋白家族是一种多效的转录因子，可以与多种启动子部位的KB位点发生特异性结合，从而促使其转录表达。其受氧化应激、细菌脂多糖、细胞因子等多种刺激而活化后，调控前炎症性细胞因子、细胞表面受体、转录因子、粘附分子等生成。

NNFkB主要存在于细胞质中，并与抑制性的IkB蛋白形成复合物，当IkB磷酸化之后，NFkB被释放，并转位到细胞核。NFkB在凋亡和细胞存活上有着矛盾的功能，NFkB通过抑制p53依赖的凋亡和上调Bcl-2家族的抗凋亡成员和caspase抑制剂（如XIAP和FLIP），介导了许多信号的存活反应。相反，NFkB也被DNA损伤中的凋亡刺激所激活，介导了促凋亡基因（如TRAILR2/DR5、Fas和Fas配体）的上调。

Novus NFKB信号通路相关产品

目录号 名称 种属反应性 应用
H6-NBP1-62000 c-Rel Antibody Hu WB, ELISA, IHC-P
H6-NB100-92032 FADD Antibody Hu, Ms WB, IHC-P
H6-NB100-91824 IKK alpha Antibody Hu, Mu, Rt WB, IHC-P
H6-NB100-56509 KK beta Hu, Ms ,WB FACS, IHC-P, IP
H6-NBP1-84681 IKK gamma Hu WB, ICC/IF, IHC-P
H6-NB100-2184 IL1 alpha Hu WB, ELISA
H6-NB600-633 IL1 beta Hu, Ca, Mk WB, ELISA, IHC, IP
H6-NB110-85471 IL1 Receptor Ms WB, IHC-P
H6-NBP1-61700 IRAK Hu WB, ELISA, ICC/IF, IHC-P
H6-NBP1-19785 MyD88 Hu, Mu, Rt WB, IHC-P
H6-NBP1-77395 NFkB p105/p50 Hu, Ms, WB, ICC/IF, IHC-P
H6-NBP1-96139 NFkB p65 Hu, Ms, Mk WB, ICC/IF, IHC-P
H6-NB600-201 pan PKC Hu, Mu, Rt WB, ELISA, ICC/IF, IHC-Fr, IHC-P, IP, RIA
H6-NBP1-45883 TCR-alpha Hu, Mu, Rt WB, IHC-Fr, IHC-P, IP
H6-NBP1-33357 TRAF6 Hu WB
H6-NB110-57461 RelB Hu WB, ICC/IF, IHC-P, IP

NFkB信号通路研究相关文献

1.Shapshak P. Bioinformation and molecule of the month: Multiple interactive pathways for a single gene, NFkB. Bioinformation. 2012;8(9):399-402. [PMID: 22715307].

2.Hussain AR, et al. Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL)cell lines for efficient apoptosis. PLoS One. 2012;7(6):e39945. [PMID: 22768179].

3.Morita M, et al. Advanced glycation end products-induced reactive oxygen species generation is partly through NF-kappa B activation in human aortic endothelial cells. J Diabetes Complications. 2012 Aug 31. [PMID: 22944044].

4.Malato Y, et al. NF-κB Essential Modifier is Required for Hepatocyte Proliferation and the Oval Cell Reaction after PartialHepatectomy in Mice. Gastroenterology. 2012 Aug 22. [PMID: 22922425].

5.Bianco B, et al. The nuclear factor-kB functional promoter polymorphism is associated with endometriosis and infertility. HumImmunol. 2012 Aug 16. [PMID: 22902396].联科生物代理截止时间：2017年6月30日