Novus脂类代谢研究：肥胖与糖尿病

  • Post category:生物资讯
  • Post views:2924 次访问

http://www.liankebio.com/article-information_Newsletter-944.html

作者：Novus官网 发布日期：2014-11-12 09:00

肥胖是一种常见疾病，是体内脂肪过多的表现，与脂质代谢紊乱密切相关，二者互为因果。其脂质代谢紊乱表现为摄食过多使脂肪合成的原料增加，棕色脂肪含量减少使能量消耗减少，减少素和降脂激素调节失常使脂肪合成增加，降解减少。同时也可由于脂肪动员增加使血中游离脂肪酸、甘油三酯增加，极低密度脂蛋白和低密度脂蛋白清除减少。

糖尿病的发生率在逐年增高，而糖尿病引起的脂类代谢紊乱已受到人们高度重视，正常人的脂代谢处于动态平衡状态，而糖尿病患者因其胰岛素分泌缺乏和胰岛素抵抗导致其产生脂类代谢异常。

Catalog：NBP1-26387 Product: Adropin Antibody Species: Hu, Mu, Rt, Bv Applications: WB
Catalog：NB100-2390 Product: AGPAT6 Antibody Species: Hu, Mu, Rt, Bv, Mk, Po Applications: WB
Catalog：NB100-615 Product: Caveolin 1 (7C8) Antibody Species: Hu, Mu, Rt Applications: WB, FACS, IF, IHC-P, IP
Catalog：NB110-39113 Product: GLUT1 Antibody Species: Hu, Mu, Rt, Bv, Mk, Rb Applications: WB, ICC, IF, IHC-P
Catalog：NB110-57150 Product: LPIN1 Antibody Species: Hu, Mu, Rt Applications: WB, IHC, IHC-P
Catalog：NB110-57131 Product: MRP1 (IU5C1) Antibody Species: Hu, Mu Applications: WB, IF

产品引用文献：
1.[Caveolin 1 7C8) Antibody NB100-615] Munjal C, Tyagi N, Lominadze D, Tyagi SC. Matrix metalloproteinase 9 in homocysteine induced intestinal microvascular endothelial paracellular and transcellular permeability. Journal of Cellular Biochemistry. 2011 Nov 17. [PMID: 22275073]

2.[DGAT1 Antibody NB110-41487] Li M, Paran C, Wolins NE, Horowitz JF. High muscle lipid content in obesity is not due to enhanced activation of key triglyceride esterification enzymes or to the suppression of lipolytic proteins. Am J Physiol Endocrinol Metab. 2011 Feb 1. [PMID: 21285405]

3.[Endothelial Lipase Antibody NB400-118] Riederer M, Trbuši M, Degoricija V, Frank S. Endothelial Lipase Plasma Levels are Increased in Patients With Significant Carotid Artery Stenosis and History of Neurological Impairment. J Clin Med Res. 2012 Jan 15;4(1):49-51. [PMID: 22383927]

4.[IRE1 alpha [p Ser724] Antibody NB100-2323] Chen K, Jin P, He H-H, et al. Overexpression of Insig-1 protects beta cell against glucolipotoxicity via SREBP-1c. J Biomed Sci. 2011 Aug 16;18(1):57. [PMID: 21843373]

5.[IRE1 alpha [p Ser724] Antibody NB100-2323] Ota A, Wang Y. Cdc37/Hsp90-mediated regulation of IRE1[alpha] activity in ER stress response and insulin synthesis in INS-1 cells. The Journal of Biological Chemistry.

6.2011 Dec 23. [PMID: 22199355]

7.[NOX4 Antibody NB110-58851] Chen J, Chen JK, Harris RC. Angiotensin II Induces Epithelial- to-Mesenchymal Transition in Renal Epithelial Cells through Reactive Oxygen Species/Src/Caveolin -Mediated Activation of an Epidermal Growth Factor Receptor-Extracellular Signal-Regulated Kinase Signaling Pathway. Mol Cell Biol. 2012

8.Mar;32(5):981-91. [PMID: 22215616]

9.[Perilipin Antibody NB100-60554] Rigamonti A, Brennand K, Lau F, Cowan CA. Rapid cellular turnover in adipose tissue. PLoS ONE. 2011. [PMID 21407813]

10.[PGC-1 alpha Antibody NBP1-04676] Liu W, Singh R, Choi CS, et al. LDL Receptor Related Protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure. The Journal of Biological Chemistry. 2012 Jan 9. [PMID: 22232553]

11.[PGC-1 alpha Antibody NBP1-04676] Rebholz SL, Jones T, Burke KT, Jaeschke A, Tso P, D’Alessio DA, Woollett LA. Multiparity leads to obesity and inflammation in mothers and obesity in male offspring. Am J Physiol Endocrinol Metab. 2012 Feb;302(4):E449-57. [PMID: 22127227]联科生物代理截止时间：2017年6月30日