Novus细胞自噬研究领域的领导者

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http://www.liankebio.com/article-information_Newsletter-1201.html

作者：Novus官网 发布日期：2014-04-15 10:00

自噬是凋亡之外的第二种程序性细胞死亡方式，是进化过程中保留下来的高度保守的自我保护机制，参与自噬的基因从单细胞的酵母到植物、脊椎动物和人中均较为保守。自噬在机体稳定、组织重塑、细胞发育及内环境稳态、生物合成以及环境的适应方面等都发挥着十分重要的作用。

根据细胞内底物运送到溶酶体腔方式的不同，哺乳动物细胞自噬主要可分为三种方式（下图）：大自噬（Macroautophagy），微自噬（Microautophagy）和分子伴侣介导的自噬（Chaperone-mediated autophagy, CMA）。大自噬即我们说的自噬（autophagy）。微自噬是溶酶体直接内陷，包裹细胞质中的成分，形成一个内在的囊泡，没有形成自噬体的过程。分子伴侣介导的自噬为胞浆内蛋白结合到分子伴侣后转运到溶酶体腔中，被溶酶体酶消化。

自噬的三种主要方式（Crotzer VL., et al. 2005, Proc Natl Acad Sci USA）

Novus在细胞自噬研究领域享有相当高的声誉，细胞自噬研究相关产品列表：

目录号 产品名称 抗体来源 应用 交叉反应性 引用文献
H6-NB500-249 Beclin 1 Antibody Rabbit WB, ICC/IF, IHC,mor Hu,Ms,Rt 31
H6-NB110-87318 Beclin 1 Antibody Mouse WB, ICC/IF, IHC,more Hu,Ms,Ca,more 11
H6-NB100-2220 LC3 Antibody Rabbit WB, ICC/IF, IHC,more Hu,Ms,Rt,more 219
H6-NB100-2331 LC3 Antibody Rabbit IHC-P,IP, WB,more Hu,Ms,Rt,more 80
H6-NBP1-19167 LC3 Antibody Rabbit WB, FCM, IHC,more Hu,Ms,Rt,more 9
H6-NB600-1384 LC3B Antibody Rabbit WB, FCM, IHC,more Hu,Ms,Rt,more 86
H6-NB110-53818 ATG5 Antibody Rabbit WB, ICC/IF, IHC,more Hu,Ms,Rt,more 56
H6-NB110-56893 ATG9A Antibody Rabbit WB, IHC, IHC-P Hu,Ms,Rt,more 5

Novus自噬产品引用文献：

1. [ATG5 NB110-53818] Lee J-A, Gao F-B. Inhibition of autophagy induction delays neuronal cell loss caused by dysfunctional ESCRT-III in frontotemporal dementia. J Neurosci 2009;29(26):8506-8511.[PMID: 19571141]

2. [Beclin 1 NB110-87318] Bellot G, et al. Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol 2009;29(10):252581.[PMID: 19273585]

3. [Beclin 1 NB500-249] [Beclin 1 NB110-87318] Pattingre S, et al. Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J Biol Chem 2009;284(5):2719-2728.[PMID: 19029119]

4. [Beclin 1 NB500-249] Wang Y et al. Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus. J Biol Chem. 2008 Feb 22;283(8):4766-77. [PMID: 18073215]

5. [Calreticulin NB600-101] Baruah P, et al. C1q enhances IFN-gamma production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells. Blood 2009;113(15):3485-3493. [PMID: 19171874]

6. [LC3 NB100-2220] Dreux M, Gastaminza P, Wiel SF, et al. The autophagy machinery is required to initiate hepatitis C virus replication. PNAS 2009;106(33):14046-14051. [PMID: 19666601]

7. [LC3 NB100-2220] Fu L, et al. Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy. Cancer Res. 2009 Dec 1;69(23):8967-76. [PMID: 19920197]

8. [LC3 NB100-2220] Pacheco CD, Elrick MJ, Lieberman AP. Tau deletion exacerbates the phenotype of Niemann-Pick type C mice implicates autophagy in pathogenesis. Hum Mol Genet 2009;18(5):956-965.[PMID: 19074461]

9. [LC3 NB100-2220] Shen S, et al. Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy. J Cell Biol 2009;185(4):629-639. [PMID: 19433452]

10. [LC3 NB100-2220] Young JE, Martinez RA, La Spada AR. Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation. J Biol Chem 2009;284(4):2363-2373. [PMID: 19017649]

11. [LC3 NB100-2331] Lee IH, Finkel T. Regulation of autophagy by the p300 acetyltransferase. J Biol Chem 2009;284(10):6322-6328. [PMID: 19124466]

12. [LC3B NB600-1384] Montie HL, et al. Cytoplasmic retention of polyglutamine-exped rogen receptor ameliorates disease via autophagy in a mouse model of spinal bulbar muscular atrophy. Hum Mol Genet 2009;18(11):1937-1950. [PMID: 19279159]

13. [NOD2 NB100-524] Lipinski S, et al. DUOX2-derived reactive oxygen species are effectors of NOD2- mediated antibacterial responses. J Cell Sci 2009;122(19):3522-3530. [PMID: 19759286]

14. [Raptor NB100-766] Cully M, et al. A Role for p38 Stress-Activated Protein Kinase in Regulation of Cell Growth via TORC1. Mol Cell Biol. 2010 Jan;30(2):481-95. [PMID: 19917724]

15. [ATG9A NB110-56893] This antibody was given a review of five out of five stars, in a customer review submitted September8, 2009. The researcher used the antibody in Western Blot on human brain extract within the suggested dilution and achieved a specific band at 90 kDa. The customer stated “I was very happy to use the product and another one for LC3 from your company and would gladly recommend it for anyone interested.”- Reviewed by Panaiyur S. Mohan, Ph.D.联科生物代理截止时间：2017年6月30日