免疫检查点Immune checkpoints —抗体和蛋白

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http://www.liankebio.com/article-information_Newsletter-585.html

作者：BioVision官网 发布日期：2016-08-11 10:00

免疫检查点Immune checkpoints —抗体和蛋白
在肿瘤免疫学和免疫治疗领域的最新进展，已产生的免疫检查点蛋白的识别，可以被人抗体阻断。免疫检查点通路包含共刺激蛋白和抑制蛋白。共刺激受体转换信号促进对抗病原体的免疫功能。另一方面，抑制性受体，负调节T细胞的激活，以防止过度的炎症反应。直接针对细胞毒性T淋巴细胞抗原-4（CTLA-4）和程序性死亡-1（PD-1）的免疫调节抗体，在黑色素瘤和其他类型的肿瘤治疗中表现出巨大的希望。

这些药剂通常被称为“检查点抑制剂”，因为它们阻断正常的T细胞免疫的负调节因子。很多其他的免疫检查点途径，可能是新疗法的目标，已经确定且目前正在开发用于临床试验。Biovision提供全面的免疫检查点蛋白和抗体，支持免疫检查点阻断研究。这些产品在多种检测实验都表现出一致性和极佳的性能。

检查点阻断抗体（Checkpoint Blocking Antibodies）

Product Name Catalog No. Size Host Species Application
4-1BBL Antibody 93-5369-30T, 100 30 μg, 100 μg Rb hu WB, IHC
BTLA Polyclonal Antibody 93-A1082-50 50 μg Rb hu WB, IHC, IF
CD137 Polyclonal Antibody 93-A1088-100 100 μl Rb hu WB, ELISA, IF
CD137/4-1BB Antibody 93-A1087-50 50 μl Rb hu, ms, rt IHC
CD223 (LAG3) Polyclonal Antibody 93-A1067-100 100 μg Rb hu, ms WB, IHC, FC
CD27 Polyclonal Antibody 93-A1074-100 100 μg Rb hu WB, FC
CD28 Polyclonal Antibody 93-A1076-100 100 μg Rb hu WB, ELISA
CTLA4 Polyclonal Antibody 93-A1083-100 100 μl Rb hu WB, IHC
GITR / TNFSF18 Monoclonal Antibody 93-A1086-50 50 μg Ms hu WB
GITR / TNFSF18 Polyclonal Antibody 93-A1085-100 100 μl Rb hu WB
HVEM / TNFRSF14 Antibody 93-A1084-50 50 μg Rb hu, ms WB, IHC, IF
OX40 Antibody 93-3890-100 100 μg Rb Rt WB
PD-1/PDCD1 Antibody 93-6931-50 50 μg Rb hu WB, ELISA
Tim-3 Antibody 93-3808-100 100 μg Rb hu WB, IHC

免疫检查点蛋白（Immune Checkpoint Proteins）

Product Name Catalog No. Size Source
4-1BB Receptor, human recombinant 93-43100, -1000 100 μg, 1000 μg E. coli
CD226, human recombinant 93-7310-100 100 μg E. coli
CD40Ligand/TRAP, human recombinant 93-4014-10, -1000 10 μg, 1000 μg E. coli
Human CellExp™ 4-1BB Ligand/TNFSF9, Human recombinant 93-9240-10, -25 10 μg, 25 μg HEK293 cells
Human CellExp™ B7-2 /CD86, human recombinant 93-7496-10, -50 10 μg, 50 μg HEK293 cells
Human CellExp™ B7-H3 / CD276, Human recombinant 93-9239-10, -50 10 μg, 50 μg HEK293 cells
Human CellExp™ B7-H5 / VISTA, Human recombinant 93-9242-10, -50 10 μg, 50 μg HEK293 cells
Human CellExp™ BTLA, Human recombinant 93-9228-10, -50 10 μg, 50 μg HEK293 cells
Human CellExp™ CD155, human recombinant 93-7462-10, -50 10 μg, 50 μg HEK293 cells
Human CellExp™ CD160/BY55, human recombinant 93-7386-10, -50 10 μg, 50 μg HEK293 cells
Human CellExp™ CD172A / SIRP, human recombinant 93-7506-50 10 μg, 50 μg HEK293 cells
Human CellExp™ CD244 / 2B4 / SLAMF4, Human recombinant 93-7374-10, -50 10 μg, 50 μg HEK293 cells
Human CellExp™ CD27 / TNFRSF7, Human recombinant 93-9243-100, -25 10 μg, 25 μg HEK293 cells
Human CellExp™ CD273 / B7-DC / PD-L2, Human recombinant 93-7369-10, -50 10 μg, 50 μg HEK293 cells
Human CellExp™ CD28, Human recombinant 93-9237-10, -50 10 μg, 50 μg HEK293 cells
Human CellExp™ CD47, Human recombinant 93-7385-10 10 μg HEK293 cells
Human CellExp™ CD80, Human recombinant 93-7383-10, 50 10 μg, 50 μg HEK293 cells
Human CellExp™ CTLA4/CD152, human recombinant 93-7476-20, -100 10 μg, 100 μg HEK293 cells
Human CellExp™ GITR / TNFRSF18, Human recombinant 93-9231-10, -50 10 μg, 50 μg HEK293 cells
Human CellExp™ Human CD40/ TNFRSF5, Human recombinant 93-9230-10, -50 10 μg, 50 μg HEK293 cells
Human CellExp™ HVEM/TNFRSF14, Human recombinant 93-7466-20, -100 20 μg, 100 μg HEK293 cells
Human CellExp™ ICOS / CD278, Human recombinant 93-9238-10, -100 10 μg, 100 μg HEK293 cells
Human CellExp™ ICOSLG /B7-H2 /CD275, Human recombinant 93-7426-20, -100 20 μg, 100 μg HEK293 cells
Human CellExp™ OX40 Ligand / TNFSF4, Human recombinant 93-9244-10, -50 10 μg, 50 μg HEK293 cells
Human CellExp™ PD-1 /PDCD1, C-Fc Tag, Human recombinant 93-7500-10, -50 10 μg, 50 μg HEK293 cells
Human CellExp™ PD-1 /PDCD1, C-Fc Tag, Mouse recombinant 93-7503-10, -50 10 μg, 50 μg HEK293 cells
Human CellExp™ PD-1 /PDCD1, Human recombinant 93-7498-10, -50 10 μg, 50 μg HEK293 cells
Human CellExp™ PD-1 /PDCD1, Mouse recombinant 93-7499-10, -50 10 μg, 50 μg HEK293 cells
Human CellExp™ PD-L1 /CD274 /B7-H1, Human recombinant 93-7429-10, -50 10 μg, 50 μg HEK293 cells
Human CellExp™ PD-L1 /CD274 /B7-H1, Mouse recombinant 93-7428-10, -50 10 μg, 50 μg HEK293 cells
Human CellExp™ TIGIT, human recombinant 93-8015-10 10 μg HEK293 cells
Human CellExp™ TIM3/HAVR2 Protein, Human Recombinant 93-P1002-20, -100 20 μg, 100 μg HEK293 cells
Human CellExp™ TIM3/HAVR2 Protein, Human Recombinant 93-P1002-20, -100 20 μg, 100 μg HEK293 cells
Human CellExp™ TNFRSF4/OX40 /CD134, human recombinant 93-7438-10 10 μg HEK293 cells
Human CellExp™ VTCN1, Human recombinant 93-7412-10, -50 10 μg, 50 μg HEK293 cells
Human CellExp™LAG3 /CD223, Human recombinant 93-7278-10, -50 10 μg, 50 μg HEK293 cells
PD-1/PDCD1, Human Recombinant 93-P1024-10, -50 10 μg, 50 μg E. coli

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