Background:Considering the narrow immune response spectrum of a single epitope, and the nanoparticles (NPs) as a novel adjuvant can achieve efficient delivery of antigenic peptides safely, a nano-system (denoted as DSPE-PEG-Man@EM-NPs) based on cathepsin B-responsive antigenic peptides was designed and synthesized.
Methods:Highly affinitive antigenic peptides were delivered by self-assembled NPs, and targeted erythrocyte membranes acted as a peptide carrier to improve antigenic peptides presentation and to strengthen cytotoxic T-cells reaction. Cathepsin B coupling could release antigenic peptides rapidly in dendritic cells.
Results:Evaluations showed that DSPE-PEG-Man@EM-NPs had obvious inhibitory effects towards both MCF-7 and MDA-MB-231 human breast cancer cell lines.
Conclusion:Overall, this strategy provides a novel strategy for boosting cytotoxic T lymphocytes response, thereby expanding the adaptation range of tumor antigenic peptides and improving the therapeutic effect of tumor immunotherapy with nanomedicine.
文章引用产品列表
-
- F11003C04
- 流式抗体(新品)
Anti-Human CD3, PerCP-Cy5.5 (Clone:HIT3a) 检测试剂
- ¥1,504.00 – ¥3,264.00
-
- F11003A04
- 流式抗体(新品)
Anti-Human CD3, PerCP-Cy5.5 (Clone:SK7) 人 CD3 流式抗体 (新品)
- ¥1,332.00 – ¥2,960.00
-
- F1100304
- 流式抗体(新品)
Anti-Human CD3, PerCP-Cy5.5 (Clone:OKT3) 人 CD3 流式抗体 (新品)
- ¥600.00 – ¥1,320.00