Hydrolyzed chicken meat extract boosts the immunoregulatory effect by regulating M1/M2 Macrophage polarization

Hydrolyzed chicken meat extract (HCE) has previously been shown to mitigate inflammation and oxidative stress, and enhance cognitive function in humans. However, it is still not clear whether HCE and its bioactive components (BC) could affect immune function. Herein, we found that both HCE and BC administration promoted the phagocytic activity and attenuated the oxidative stress in RAW 264.7 cells. Moreover, HCE and BC treatment caused a significant decrease in M1 macrophage activation and an increase in M2 macrophage activation in RAW264.7 cells and peritoneal macrophages, resulting in an M2 dominant shift in macrophages. These effects of HCE and BC might be partly regulated by suppressing the MAPK and NF-κB pathways and enhancing the STAT6 and Akt pathways. Cyclo(Val-Pro) isolated from BC exerted clear anti-inflammatory and antioxidative effects, which might be partly responsible for the impacts of HCE and BC. Therefore, HCE and BC might serve as potential immunoregulatory agents.

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