Interfacial engineered living drugs with an “ON/OFF” switching for oral delivery

Living drugs offer a new frontier in medicine, paving the way for personalized and potentially curative treatments. A customized living drug generally requires specialized technologies for highly effective and selective delivery to lesion location. In this article, we explored an interfacial engineering method for living drugs by wrapping with a “stealth coating”, realizing an “ON/OFF” switching of the communications of probiotics and GI tract. This maximized the bioactivity of living drugs following oral administration to exempt acidic insults, and then significantly improved the retention through gastrointestinal tract. With notable ability to improve the oral availability, the interfacial engineered living drugs with a “stealth coating” represent remarkable effects for enhanced oral delivery and treatment efficacy in DSS-induced acute colitis model. We believe this work will have potential to revolutionize medicine by precise targeting and increasing curative activity on the future of disease treatment.