Mir-1273g-3p Modulates Activation and Apoptosis of Hepatic Stellate Cells by Directly Targeting Pten in Hcv-Related Liver Fibrosis

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  • 作者：Niu, X., Fu, N., Du, J., Wang, R., Wang, Y., Zhao, S., Du, H., Wang, B., Zhang, Y., Sun, D. & Nan, Y.
  • 期刊：FEBS letters 590, 2709-2724 (2016)
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MicroRNA (miRNA) play a pivotal role in the development of liver fibrosis. However, the functions of miRNA in hepatitis C virus (HCV)-related liver fibrosis remain unclear. In this study, we systematically analyzed the microarray data of the serum miRNA in patients with HCV-induced hepatic fibrosis. Among 41 dysregulated miRNA, miR-1273g-3p was the most significantly upregulated miRNA and correlated with the stage of liver fibrosis. Overexpression of miR-1273g-3p could inhibit translation of PTEN, increase the expression of α-SMA, Col1A1, and reduce apoptosis in HSCs. Hence, we conclude that miR-1273g-3p might affect the activation and apoptosis of HSCs by directly targeting PTEN in HCV-related liver fibrosis.

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