2023年11月4日，暨南大学、暨南大学第一附属医院和清华深圳国际研究生院的Shuran Fan、Jinghua Pan、Minfeng Chen等团队在Acta Pharmaceutica Sinica B（IF=14.5）在线发表题为“Targeting FAPa-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis”的研究论文，该研究强调了成纤维细胞活化蛋白α（FAPa）在结直肠癌癌症淋巴结转移（CRCLNM）肿瘤细胞中的作用，并为CRCLNM提供了一个潜在的治疗靶点和有前景的策略。此论文使用了联科生物Mouse Regulatory T Cell Staining Kit（货号：KTR201）和Human VEGFC ELISA Kit（货号：EK1154）2种检测试剂盒。
(G) Flow cytometry analysis of CD4+CD25+FOXP3+ Treg cells in metastatic LN tissues from MC38Vector and MC38FAP allografts (n = 5).
(J) ELISA analysis of VEGFC in hLECs treated with conditioned medium from SW480 or SW620 cells in the absence or presence of CTS (n=3).
目前淋巴结转移性癌症（LNM-CRC）细胞的性质尚不清楚，并且仍然缺乏有效的治疗方法。本篇研究发现缺氧诱导LNM-CRC细胞中FAPa的表达。增益或损失功能实验表明，FAPa通过激活STAT3通路增强了肿瘤细胞的迁移、侵袭、上皮-间质转变、干性和淋巴管生成。此外，FAPa在肿瘤细胞中诱导细胞外基质重塑并建立免疫抑制环境，通过募集调节性T细胞，促进CRCLMM。Z-GP-DA-VLBH是一种FAPa激活的前药，通过靶向FAPa阳性的LNM-CRC细胞来抑制CRCLNM，为CRCLNM提供了一个潜在的治疗靶点和治疗策略。
联科生物产品助力生命科学研究
KTR201 kit Mouse Regulatory T Cell Staining Kit
1. A pH-responsive polymersome depleting regulatory T cells and blocking A2A receptor for cancer immunotherapy
2. Targeting FAPa-positive lymph node metastatic tumor cells suppresses colorectal cancer Metastasis
3. Short-term administration of Qipian®, a mixed bacterial lysate, inhibits airway inflammation in ovalbumin-induced mouse asthma by modulating cellular, humoral and neurogenic immune responses.
EK1154 Human VEGFC ELISA Kit
1. Targeting FAPa-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis
参考文献：Shuran Fan, Ming Qi, Qi Qi, Qun Miao, Lijuan Deng, Jinghua Pan, Shenghui Qiu, Jiashuai He, Maohua Huang, Xiaobo Li, Jie Huang, Jiapeng Lin, Wenyu Lyu, Weiqing Deng, Yingyin He, Xuesong Liu, Lvfen Gao, Dongmei Zhang, Wencai Ye, Minfeng Chen,Targeting FAPα-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis,Acta Pharmaceutica Sinica B,2023
原文链接：https://www.sciencedirect.com/science/article/pii/S2211383523004240
