LAG3 靶点信息

LAG3 分子靶点信息概述

  • 分子名：LAG3, lymphocyte activating 3
  • 基因家族：CD molecules; Immunoglobulin like domain containing
  • 别名：CD223
  • 全称：lymphocyte-activation gene 3

LAG3 分子靶点综述

CD223，又名淋巴细胞活化基因-3(LAG-3)，是免疫球蛋白超家族成员之一，是对淋巴细胞具有抑制作用的分子。LAG-3 分子与 CD4 分子具有密切的相关性，这两个分子的基因都定位于第 12 号染色体的短臂末端。LAG-3 分子主要表达于活化的 NK 细胞、T 淋巴细胞表面，与 MHC II 高亲和力结合。

LAG3, lymphocyte activating 3 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human LAG3 分子靶点信息

  • 分子名：LAG3, lymphocyte activating 3
  • 别称：
    • CD223
    • lymphocyte activation gene 3 protein
    • lymphocyte-activation gene 3
  • 基因序列：NCBI_Gene: 3902
  • 蛋白序列：UniProtKB: P18627

人 Human LAG3靶点分子功能（预测）

Enables MHC class II protein binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of regulatory T cell differentiation; and plasmacytoid dendritic cell activation. Predicted to act upstream of or within negative regulation of T cell activation; negative regulation of interleukin-2 production; and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in extracellular region.

小鼠 Mouse Lag3 分子靶点信息

小鼠 Mouse Lag3 靶点分子功能（预测）

Enables MHC class II protein binding activity and transmembrane signaling receptor activity. Involved in negative regulation of regulatory T cell differentiation; plasmacytoid dendritic cell activation; and regulation of immune response. Acts upstream of or within cell surface receptor signaling pathway; negative regulation of interleukin-2 production; and positive regulation of natural killer cell mediated cytotoxicity. Located in external side of plasma membrane and extracellular region. Orthologous to human LAG3 (lymphocyte activating 3).

大鼠 Rat Lag3 分子靶点信息

  • 分子名：Lag3, lymphocyte activating 3
  • 别称：
    • CD223
    • LAG-3
    • LOC297596
    • lymphocyte activation gene 3 protein
    • lymphocyte-activation gene 3
    • MGC108901
  • 基因序列：NCBI_Gene: 297596
  • 蛋白序列：UniProtKB: Q5BK54

大鼠 Rat Lag3 靶点分子功能（预测）

Predicted to enable MHC class II protein binding activity and transmembrane signaling receptor activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of regulatory T cell differentiation; and plasmacytoid dendritic cell activation. Predicted to act upstream of or within negative regulation of T cell activation; negative regulation of interleukin-2 production; and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in external side of plasma membrane and extracellular region. Orthologous to human LAG3 (lymphocyte activating 3).

LAG3 分子产品列表

LAG3 分子靶点最新资讯

免疫检查点Immune checkpoints —抗体和蛋白