ITGAM 靶点信息

ITGAM 分子靶点信息概述

  • 分子名：ITGAM, integrin subunit alpha M
  • 基因家族：CD molecules; Integrin alpha subunits; Complement system regulators and receptors
  • 别名：MAC-1; CD11b
  • 曾用名：CR3A; CD11B
  • 全称：complement component 3 receptor 3 subunit; macrophage-1 antigen alpha subunit; integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide); integrin, alpha M (complement component 3 receptor 3 subunit)

ITGAM 分子靶点综述

CD11b与CD18非共价结合，形成αM-β2整合素(Mac-1)，与CD54(ICAM-1)、C3bi和纤维蛋白原结合。Mac-1表达于巨噬细胞、NK细胞、粒细胞、小胶质细胞、活化的淋巴细胞和小鼠B-1细胞。CD11b与其配体结合，参与粘附细胞的互相作用。此抗体也可交叉识别人CD11b，可检测人外周血中单核细胞、粒细胞和某一群NK细胞上的该抗原。

ITGAM, integrin subunit alpha M 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human ITGAM 分子靶点信息

  • 分子名：ITGAM, integrin subunit alpha M
  • 别称：
    • antigen CD11b (p170)
    • CD11 antigen-like family member B
    • CD11B
    • cell surface glycoprotein MAC-1 subunit alpha
    • complement component 3 receptor 3 subunit
    • CR-3 alpha chain
    • CR3A
    • integrin alpha-M
    • integrin, alpha M (complement component 3 receptor 3 subunit)
    • integrin, alpha M (complement component receptor 3, alpha)
    • leukocyte adhesion receptor MO1
    • MAC-1
    • MAC1A
    • macrophage antigen alpha polypeptide
    • macrophage-1 antigen alpha subunit
    • MGC117044
    • MO1A
    • neutrophil adherence receptor alpha-M subunit
    • SLEB6
  • 基因序列：NCBI_Gene: 3684
  • 蛋白序列：UniProtKB: P11215

人 Human ITGAM靶点分子功能（预测）

Enables heat shock protein binding activity. Involved in ectodermal cell differentiation; positive regulation of neutrophil degranulation; and positive regulation of superoxide anion generation. Located in cell surface; extracellular space; and plasma membrane raft. Implicated in lupus nephritis.

小鼠 Mouse Itgam 分子靶点信息

  • 分子名：Itgam, integrin alpha M
  • 别称：
    • Cd11b
    • CD11B (p170)
    • CD11b/CD18
    • complement component receptor 3 alpha
    • complement receptor type 3
    • CR3
    • F730045J24Rik
    • Ly-40
    • lymphocyte antigen 40
    • Mac-1
    • Mac-1 alpha
    • Mac-1a
    • macrophage antigen alpha chain (integrin)
    • RIKEN cDNA F730045J24 gene
  • 基因序列：NCBI_Gene: 16409
  • 蛋白序列：

小鼠 Mouse Itgam 靶点分子功能（预测）

Enables complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Contributes to cargo receptor activity. Involved in several processes, including central nervous system development; endocytosis; and positive regulation of neuron death. Acts upstream of or within several processes, including activated T cell proliferation; leukocyte migration; and microglia development. Located in external side of plasma membrane and nucleus. Is integral component of membrane. Part of integrin alphaM-beta2 complex. Is expressed in several structures, including central nervous system; heart; lymphatic vessel; thymus; and yolk sac. Human ortholog(s) of this gene implicated in lupus nephritis. Orthologous to human ITGAM (integrin subunit alpha M).

大鼠 Rat Itgam 分子靶点信息

大鼠 Rat Itgam 靶点分子功能（预测）

Predicted to enable several functions, including complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Predicted to contribute to cargo receptor activity. Predicted to be involved in several processes, including endocytosis; positive regulation of myeloid leukocyte mediated immunity; and positive regulation of neuron death. Predicted to act upstream of or within several processes, including activated T cell proliferation; leukocyte migration; and microglia development. Predicted to be located in several cellular components, including external side of plasma membrane; extracellular space; and plasma membrane raft. Predicted to be integral component of membrane. Predicted to be part of integrin alphaM-beta2 complex. Human ortholog(s) of this gene implicated in lupus nephritis. Orthologous to human ITGAM (integrin subunit alpha M).

ITGAM 分子产品列表

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