INS 分子靶点信息 - INS分子别称 | 人/小鼠/大鼠INS分子靶点功能 | INS分子靶点检测

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INS 分子靶点信息概述
INS 分子靶点综述
INS, insulin 分子靶点种属信息
INS 分子产品列表
Human/Canine/Porcine Insulin ELISA Kit检测试剂盒（酶联免疫吸附法）
Human/Canine/Porcine Insulin Standard (人/犬/猪胰岛素标准品)
Rat Insulin Competitive Standard (大鼠胰岛素竞争法标准品)
Mouse/Rat Insulin Competitive ELISA Kit 检测试剂盒（酶联免疫吸附法）
INS 分子靶点最新资讯

INS 分子靶点信息概述

分子名：INS, insulin
基因家族：Neuropeptides
曾用名：IDDM2; IDDM1
全称：insulin-dependent diabetes mellitus 2

INS 分子靶点综述

胰岛素是一种由胰岛β细胞和一些硬骨鱼布氏体分泌产生的肽类激素。它通过促进脂肪、肝脏和骨骼肌细胞吸收血液中的葡萄糖，从而对糖类、脂肪和蛋白质代谢起重要作用。这些组织吸收的葡萄糖转化为糖原或者脂肪(甘油三酯)，而肝脏是个例外，其吸收的葡萄糖可以转化为糖原和脂肪。肝脏中的葡萄糖产量受血液中高浓度胰岛素强烈抑制。血液中胰岛素浓度高时，它就是一种同化激素，可促进血液中的小分子转化为细胞内的大分子。血液中胰岛素浓度低时，它通过促进广泛的分解代谢而产生相反的效果。当胰岛β细胞被自身免疫过程破坏，胰岛素就不再合成或者分泌到血液中，进而导致 1 型糖尿病。遗传易感性和环境因素的综合影响会导致胰岛素抵抗，这就是 2 型糖尿病。另外，胰岛β细胞产生过量的胰岛素或反应性低血糖都与胰岛素瘤有关。

INS, insulin 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human INS 分子靶点信息

分子名：INS, insulin
别称：
- IDDM
- IDDM1
- IDDM2
- ILPR
- insulin-dependent diabetes mellitus 2
- IRDN
- MODY10
- PNDM4
- preproinsulin
- proinsulin
基因序列：NCBI_Gene: 3630
蛋白序列：UniProtKB: P01308

人 Human INS靶点分子功能（预测）

Enables identical protein binding activity; protease binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of signal transduction; regulation of generation of precursor metabolites and energy; and regulation of protein metabolic process. Located in extracellular space. Implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Biomarker of disease of metabolism (multiple); osteoarthritis; pancreatic ductal carcinoma; and prostate cancer.

小鼠 Mouse Ins2 分子靶点信息

分子名：Ins2, insulin II
别称：
- AA986540
- expressed sequence AA986540
- Ins-2
- InsII
- maturity onset diabetes of the young
- maturity onset diabetes of the young 4
- Mody
- Mody4
基因序列：NCBI_Gene: 16334
蛋白序列：

小鼠 Mouse Ins2 靶点分子功能（预测）

Predicted to enable identical protein binding activity; protease binding activity; and signaling receptor binding activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and positive regulation of phosphorylation. Located in cytosol; nucleus; and secretory granule. Part of sno(s)RNA-containing ribonucleoprotein complex. Is expressed in several structures, including brain; extraembryonic component; gut; immune system; and testis. Used to study maturity-onset diabetes of the young; neonatal diabetes; permanent neonatal diabetes mellitus; type 1 diabetes mellitus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to several human genes including INS (insulin).

大鼠 Rat Ins2 分子靶点信息

分子名：Ins2, insulin 2
别称：
- C-peptide
- CP-II
- insulin-2
- LOC102549619
- uncharacterized LOC102549619
基因序列：NCBI_Gene: 24506
蛋白序列：UniProtKB: P01323

大鼠 Rat Ins2 靶点分子功能（预测）

Predicted to enable several functions, including identical protein binding activity; signaling receptor binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including negative regulation of catabolic process; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and positive regulation of phosphorylation. Located in extracellular space. Colocalizes with secretory granule. Used to study hypertension. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to human INS (insulin).