IL4 靶点信息

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IL4 分子靶点信息概述

  • 分子名：IL4, interleukin 4
  • 基因家族：Interleukins
  • 别名：BSF1; IL-4; BCGF1; BCGF-1; MGC79402
  • 全称：B_cell stimulatory factor 1; lymphocyte stimulatory factor 1; B cell growth factor 1

IL4 分子靶点综述

IL-4是II型辅助T细胞(Th2细胞)分泌的细胞因子。IL-4是一种多效性细胞因子，在调节T、B淋巴细胞和其他类型细胞的增殖、分化、凋亡，促进以Th2细胞为特征的免疫应答过程中发挥重要作用。IL-4多重生物效应依赖于细胞类型和分化状态，研究表明其在介导过敏性疾病、自身免疫性疾病、感染性疾病、肿瘤等疾病的免疫反应中有多重作用，对肿瘤、自身免疫性疾病和感染性疾病等有治疗作用，并且IL-4对疫苗免疫应答具有调节作用。

IL4, interleukin 4 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL4 分子靶点信息

  • 分子名：IL4, interleukin 4
  • 别称：
    • B cell growth factor 1
    • B_cell stimulatory factor 1
    • B-cell stimulatory factor 1
    • BCGF-1
    • BCGF1
    • binetrakin
    • BSF-1
    • BSF1
    • IL-4
    • interleukin 4 variant 2
    • interleukin-4
    • lymphocyte stimulatory factor 1
    • MGC79402
    • pitrakinra
  • 基因序列：NCBI_Gene: 3565
  • 蛋白序列：UniProtKB: P05112

人 Human IL4靶点分子功能（预测）

Predicted to enable cytokine activity. Involved in several processes, including negative regulation of cellular response to transforming growth factor beta stimulus; negative regulation of complement-dependent cytotoxicity; and positive regulation of macromolecule metabolic process. Acts upstream of or within positive regulation of cell migration and positive regulation of cell population proliferation. Predicted to be located in external side of plasma membrane. Predicted to be active in extracellular space. Implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Biomarker of several diseases, including allergic rhinitis; alopecia universalis; anogenital venereal wart; autoimmune disease (multiple); and liver disease (multiple).

小鼠 Mouse Il4 分子靶点信息

小鼠 Mouse Il4 靶点分子功能（预测）

Enables cytokine activity. Involved in several processes, including innate immune response in mucosa; negative regulation of white fat cell proliferation; and regulation of gene expression. Acts upstream of or within several processes, including T-helper cell differentiation; positive regulation of macromolecule metabolic process; and regulation of leukocyte activation. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; colon; hemolymphoid system; liver; and placenta. Used to study Sjogren's syndrome; atopic dermatitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Orthologous to human IL4 (interleukin 4).

大鼠 Rat Il4 分子靶点信息

  • 分子名：Il4, interleukin 4
  • 别称：
    • B-cell growth factor 1
    • B-cell IGG differentiation factor
    • B-cell stimulatory factor 1
    • BSF-1
    • IL-4
    • Il4e12
    • interleukin-4
    • lymphocyte stimulatory factor 1
  • 基因序列：NCBI_Gene: 287287
  • 蛋白序列：

大鼠 Rat Il4 靶点分子功能（预测）

Predicted to enable cytokine activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of leukocyte migration; and regulation of defense response. Located in extracellular space. Used to study anti-basement membrane glomerulonephritis; autoimmune thyroiditis; and pelvic inflammatory disease. Biomarker of several diseases, including cerebrovascular disease (multiple); interstitial lung disease (multiple); irritant dermatitis; primary biliary cholangitis; and rhinitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Orthologous to human IL4 (interleukin 4).

IL4 分子产品列表

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