IL3RA 靶点信息

IL3RA 分子靶点信息概述

  • 分子名：IL3RA, interleukin 3 receptor subunit alpha
  • 基因家族：CD molecules; Interleukin receptors; Pseudoautosomal region 1
  • 别名：CD123
  • 全称：interleukin 3 receptor, alpha (low affinity)

IL3RA 分子靶点综述

CD123是一个70 kD的跨膜分子，属于IL-3受体的α链。CD123可以单独低亲和力结合IL-3，如果与CDw131 (β链)连接，就能以高亲和力结合IL-3。CD123单独结合IL-3不会传导细胞内信号，需要β链的协助。CD123通常表达在髓系前体细胞、巨噬细胞、树突状细胞、肥大细胞、嗜碱粒细胞、巨核细胞和一些B细胞。

IL3RA, interleukin 3 receptor subunit alpha 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL3RA 分子靶点信息

  • 分子名：IL3RA, interleukin 3 receptor subunit alpha
  • 别称：
    • CD123
    • CD123 antigen
    • hIL-3Ra
    • IL-3 receptor alpha SP2 isoform
    • IL-3 receptor subunit alpha
    • IL-3R subunit alpha
    • IL-3R-alpha
    • IL-3RA
    • IL3R
    • IL3RAY
    • IL3RX
    • IL3RY
    • interleukin 3 receptor, alpha (low affinity)
    • interleukin-3 receptor subunit alpha
    • MGC34174
  • 基因序列：NCBI_Gene: 3563
  • 蛋白序列：UniProtKB: P26951

人 Human IL3RA靶点分子功能（预测）

Predicted to enable cytokine receptor activity and interleukin-3 binding activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to act upstream of or within interleukin-3-mediated signaling pathway; monocyte differentiation; and regulation of cell growth. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane.

小鼠 Mouse Il3ra 分子靶点信息

小鼠 Mouse Il3ra 靶点分子功能（预测）

Enables interleukin-3 binding activity and interleukin-3 receptor activity. Acts upstream of or within interleukin-3-mediated signaling pathway; monocyte differentiation; and regulation of cell growth. Located in membrane. Is expressed in several structures, including cardiovascular system mesenchyme; dorsal aorta; early conceptus; genitourinary system; and umbilical or vitelline vessel. Orthologous to human IL3RA (interleukin 3 receptor subunit alpha).

大鼠 Rat Il3ra 分子靶点信息

  • 分子名：Il3ra, interleukin 3 receptor subunit alpha
  • 别称：
    • Cyrl
    • cytokine receptor-like protein CYRL
    • interleukin 3 receptor, alpha
    • interleukin 3 receptor, alpha chain
    • interleukin-3 receptor subunit alpha
  • 基因序列：NCBI_Gene: 246144
  • 蛋白序列：UniProtKB: E9PSX4

大鼠 Rat Il3ra 靶点分子功能（预测）

Predicted to enable interleukin-3 binding activity and interleukin-3 receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to act upstream of or within interleukin-3-mediated signaling pathway; monocyte differentiation; and regulation of cell growth. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to human IL3RA (interleukin 3 receptor subunit alpha).

IL3RA 分子产品列表

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